ArticleJournal of neurosurgery. Case lessons2022
Correlation of intraventricular nicardipine for refractory vasospasm in aneurysmal subarachnoid hemorrhage with improved neurophysiology on intracranial multimodality monitoring: illustrative case.
Article in Journal of neurosurgery. Case lessons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Low-dose nicardipine during cardiopulmonary bypass improves carotid hemodynamics in CABG patients: a randomized controlled trial.Journal of cardiothoracic surgery · 2025Trial
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral vasospasm after aneurysmal subarachnoid hemorrhage can lead to considerable mortality and morbidity affecting the intracranial vessels, leading to delayed cerebral ischemia and stroke. Therapeutic options for patients with treatment-refractory vasospasm are limited, particularly in the setting of significant cardiopulmonary disease. Administration of nicardipine, a calcium channel blocker, into the intrathecal space may represent a potential treatment option for this population. OBSERVATIONS: A 56-year-old woman had treatment-refractory vasospasm, severe acute respiratory distress syndrome, and Takotsubo cardiomyopathy. As an adjunct to vasopressor administration and endovascular intraarterial calcium channel blocker administration, the patient received intraventricular nicardipine. The patient demonstrated improved neurophysiology on invasive multimodality neuromonitoring, with increased cerebral blood flow and oxygenation as a result of intraventricular nicardipine administration. LESSONS: Intraventricular nicardipine can be used as rescue therapy for patients with treatment-refractory cerebral vasospasm. This case demonstrates that intrathecal nicardipine may prevent delayed ischemic neurological deficits and improve outcomes.
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