Evidence map›Paper›PMID 35734507›Full record

ReviewJournal of pain research2022

Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature.

Sandra J Drozdz, Akash Goel, Matthew W McGarr, Joel Katz, Paul Ritvo, Gabriella F Mattina, Venkat Bhat, Calvin Diep, Karim S Ladha

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06036511 (Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD), which is not on this map. Cited by 61 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06036511 phase1 / phase2withdrawnnot on this mapstarted 2023, after this paper: background citation

Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD

TypeinterventionalSponsorUniversity of New MexicoRan2023 to 2023Enrolled0ConditionsPTSDArmsKetamine Hydrochloride
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Trial
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  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
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  17. Anxiety and depression in emerging adults: The STAND program as a model of scalable screening and intervention.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandra J DrozdzDepartment of Anesthesia, St. Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0001-7601-3295
Akash GoelDepartment of Anesthesia, St. Michael's Hospital, Toronto, ON, Canada.
Matthew W McGarrTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-6432-427X
Joel KatzDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-8686-447X
Paul RitvoDepartment of Psychology, York University, Toronto, ON, Canada.
Gabriella F MattinaDepartment of Anesthesia, St. Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-6205-4261
Venkat BhatInterventional Psychiatry Program, St. Michael's Hospital, Toronto, ON, Canada.
Calvin DiepDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Karim S LadhaDepartment of Anesthesia, St. Michael's Hospital, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, ketamine is used in treating multiple pain, mental health, and substance abuse disorders due to rapid-acting analgesic and antidepressant effects. Its limited short-term durability has motivated research into the potential synergistic actions between ketamine and psychotherapy to sustain benefits. This systematic review on ketamine-assisted psychotherapy (KAP) summarizes existing evidence regarding present-day practices. Through rigorous review, seventeen articles that included 603 participants were identified. From available KAP publications, it is apparent that combined treatments can, in specific circumstances, initiate and prolong clinically significant reductions in pain, anxiety, and depressive symptoms, while encouraging rapport and treatment engagement, and promoting abstinence in patients addicted to other substances. Despite much variance in how KAP is applied (route of ketamine administration, ketamine dosage/frequency, psychotherapy modality, overall treatment length), these findings suggest psychotherapy, provided before, during, and following ketamine sessions, can maximize and prolong benefits. Additional large-scale randomized control trials are warranted to understand better the mutually influential relationships between psychotherapy and ketamine in optimizing responsiveness and sustaining long-term benefits in patients with chronic pain. Such investigations will assist in developing standardized practices and maintenance programs.

Indexed as

addictionalternative treatmentanesthesiachronic painmental healthnovel therapeutic

Identifiers

PMID35734507
PMCPMC9207256

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.