ArticleActa clinica Croatica2021
MATERNAL GUT MICROBIOTA IN PREGNANCIES RESULTING IN DOWN SYNDROME NEWBORNS - A PILOT STUDY.
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Article in Acta clinica Croatica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early-Life Microbiome and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.Current neuropharmacology · 2026Pooled it
- Down-Syndrome-Related Maternal Dysbiosis Might Be Triggered by Certain Classes of Antibiotics: A New Insight into the Possible Pathomechanisms.Antibiotics (Basel, Switzerland) · 2023Article
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Authors and funding
10 authors.
Mehmet Hursitoglu1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Alev Kural1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Sibel Kuras1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Esra Akdeniz1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Salim Sezer1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Sema Suzen Caypinar1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Cemal Kazezoglu1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Bulent Yaprak1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Faruk Karandere1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Hamit Zafer Guven1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down syndrome (DS) is one of the main genetic abnormalities of newborns. Therefore, prenatal diagnosis of this syndrome is of paramount importance to the family and the community. The microbiota system is important in early brain development. We tried to study and compare gut microbiota (GM) composition in pregnancies that resulted in DS neonates with pregnancies that resulted in healthy children. The study population consisted of 21 pregnant women having delivered DS newborns (group 1) and 22 pregnant women who had given birth to healthy newborns (group 2). The GM composition was determined and compared between the two groups. There were no significant age and gestational age differences between the two groups (p>0.005 both). Regarding GM analysis, microorganisms of the families
Indexed as
Down SyndromeGastrointestinal MicrobiomeChildFemaleHumansInfant, NewbornPilot ProjectsPregnancyPrenatal DiagnosisBrainDown syndromeMicrobiotaOutcomePregnancyScreening
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