ArticleFrontiers in neurology2022
Sensorimotor Responses in Post-Stroke Hemiplegic Patients Modulated by Acupuncture at Yanglingquan (GB34): A fMRI Study Using Intersubject Functional Correlation (ISFC) Analysis.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Neuroimaging evidence of acupuncture in cognitive impairment following ischemic stroke: a systematic review.Frontiers in neuroscience · 2025Pooled it
- A systematic review of alterations in brain activation and intensity following stroke: implications for integration and functional outcomes.Frontiers in neurology · 2025Pooled it
- Real-time change in dynamic cerebral autoregulation after acupuncture at GB34 (Yanglingquan): a self-controlled study.Frontiers in physiology · 2026Trial
- Acupuncture Activates PI3K/Akt Pathway to Promote Spinal Microglial M2 Polarization and Alleviate Spastic Hemiplegia Following Ischemic Stroke.Journal of inflammation research · 2026Article
- Magnetic resonance imaging studies on acupuncture therapy in cerebral ischemic stroke: A systematic review.Heliyon · 2024Article
- Electroacupuncture at Traditional Acupoints or Myofascial Trigger Points for Chronic Nonspecific Low Back Pain: High or Alternated Frequency? A Double-Blinded Randomized Controlled Trial.Medical acupuncture · 2024Article
- Article
- Multi-scale analysis of acupuncture mechanisms for motor and sensory cortex activity based on SEEG data.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Efficacy and cerebral mechanisms of acupuncture for chronic obstructive pulmonary disease: study protocol for a multicenter, randomized controlled neuroimaging trial.Frontiers in neurology · 2024Article
- A multimodal MRI study of XNKQ acupuncture for limb dysfunction after ischemic stroke: a randomized controlled study protocol.Frontiers in neurology · 2024Article
- Neuroimaging mechanisms of acupuncture on functional reorganization for post-stroke motor improvement: a machine learning-based functional magnetic resonance imaging study.Frontiers in neuroscience · 2023Article
- Immediate neural effects of acupuncture manipulation time for stroke with motor dysfunction: a fMRI pilot study.Frontiers in neuroscience · 2023Article
- Effects of acupoints-based TENS combined with tDCS on spasticity and motor function in ischemic stroke with spastic hemiplegia: study protocol for a randomized controlled trial.Frontiers in neurology · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor dysfunction is common in patients with stroke. Acupuncture has become an acceptable alternative method for stroke rehabilitation. Previous studies have shown various functional connectivity changes activated by acupuncture. We introduced intersubject correlation (ISC) and intersubject functional correlation (ISFC) analyses into the functional magnetic resonance imaging (fMRI) for ischemic stroke to seek a common activation and suppression pattern triggered by acupuncture. In this study, 63 ischemic stroke patients with motor dysfunction and 42 normal controls were analyzed. Three functional scans were conducted during the resting state, motor task, and acupuncture at Yanglingquan (GB34) task. Twenty-two sensory, motor, and movement-imagination cortices in the bilateral hemispheres were selected as the region of interest (ROI). We performed ISC and ISFC analyses among these ROIs in three fMRI runs on patients and controls. Subgroup analyses by course or severity were also conducted. The results showed that acupuncture at GB34 triggered ISFC among upper limb motor, upper limb/hand/face, lower limb, tongue/larynx sensory, and movement imagination regions in the patient group. Subgroup ISC and ISFC analyses showed that patients tended to have increasing responses in the early stage of stroke (within 1 month) and decreasing responses afterward (1-3 months). Patients with mild clinical functional damage (NIHSS 2-4) tended to generate more responses
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