ArticleResearch square2022
SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodeling.
Silvia Torices, Carolline Motta, Barbara da Rosa, Anne Marcos, Liandra Alvarez-Rosa, Michele Siqueira, Thaidy Moreno-Rodriguez, Aline Matos, Braulia Caetano, Jessica Martins and 8 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors at 6 institutions in 3 countries.
Silvia ToricesUniversity of Miami Miller School of Medicine.
Carolline MottaFundacao Oswaldo Cruz.
Barbara da RosaFundacao Oswaldo Cruz.
Anne MarcosFundacao Oswaldo Cruz.
Liandra Alvarez-RosaFundacao Oswaldo Cruz.
Michele SiqueiraUniversidade Federal do Rio de Janeiro.
Thaidy Moreno-RodriguezUniversity of California San Francisco.
Aline MatosLaboratório de Vírus Respiratório e do Sarampo, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Braulia CaetanoFundacao Oswaldo Cruz.
Jessica MartinsFundacao Oswaldo Cruz.
Luis GladulichFundacao Oswaldo Cruz.
Olivia BagshawBrock University.
Jeffrey StuartBrock University.
Marilda SiqueiraOswaldo Cruz Foundation.
Joice StipurskyUniversidade Federal do Rio de Janeiro.
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BRBrock University · CAUniversity of Miami · USUniversidade Federal Fluminense · BRUniversity of California, San Francisco · US
Funding
Tat, amyloid beta and brain endothelial barrier functionR01MH072567 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Michal Toborek · 2005 to 2026
$7.6MRole of cerebral vasculature in brain ischemia in HIV infectionR01HL126559 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2014 to 2024
$3.8MTo evaluate the role of cannabinoid signaling during the comorbidity of HIV and Alzheimer¿s disease in the context of HIV-associated cognitive disordersR01DA040537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2015 to 2019
$3.0MTargeting Inflammasomes in Substance Abuse and HIVR01DA050528 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2020 to 2024
$2.3MDefining brain pericytes as a novel and myeloid-derived HIV reservoirR01MH128022 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2021 to 2025
$2.3MPrevention of HIV and drug abuse-induced brain pathology by targeting mitochondriaR01DA044579 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2017 to 2021
$2.2MA new pathway of spinal neurons in neuropathic pain induced by HIV with opioidR01DA047157 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN · 2018 to 2022
$2.1MRole of the BBB in HIV brain infection during methamphetamine abuseR01DA039576 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2015 to 2019
$2.0MNovel role of inflammasome activation in ART neurotoxicityR21MH122235 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2020 to 2021
$422kNHLBI NIH HHS R01 HL126559NIDA NIH HHS R01 DA039576NIDA NIH HHS R01 DA040537NIDA NIH HHS R01 DA044579NIDA NIH HHS R01 DA047157NIDA NIH HHS R01 DA050528NIMH NIH HHS R01 MH072567NIMH NIH HHS R01 MH128022NIMH NIH HHS R21 MH122235
6 · The paper itselfAbstract
Neurological effects of COVID-19 and long-COVID-19 as well as neuroinvasion by SARS-CoV-2 still pose several questions and are of both clinical and scientific relevance. We described the cellular and molecular effects of the human brain microvascular endothelial cells (HBMECs)
Identifiers
PMID35734086
PMCPMC9216729
OpenAlexW4282975436
What OpenQuestion holds
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