Evidence map›Paper›PMID 35734085›Full record

ArticlebioRxiv : the preprint server for biology2022

Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses.

Edward R Kastenhuber, Jared L Johnson, Tomer M Yaron, Marisa Mercadante, Lewis C Cantley

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Edward R KastenhuberMeyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Jared L JohnsonMeyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Tomer M YaronMeyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Marisa MercadanteMeyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Lewis C CantleyMeyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Cornell University · US

Funding

Role of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2M
NCI NIH HHS R35 CA197588
6 · The paper itself

Abstract

Previously, we showed that coagulation factors directly cleave SARS-CoV-2 spike and promote viral entry (Kastenhuber et al., 2022). Here, we show that substitutions in the S1/S2 cleavage site observed in SARS-CoV-2 variants of concern (VOCs) exhibit divergent interactions with host proteases, including factor Xa and furin. Nafamostat remains effective to block coagulation factor-mediated cleavage of variant spike sequences. Furthermore, host protease usage has likely been a selection pressure throughout coronavirus evolution, and we observe convergence of distantly related coronaviruses to attain common host protease interactions, including coagulation factors. Interpretation of genomic surveillance of emerging SARS-CoV-2 variants and future zoonotic spillover is supported by functional characterization of recurrent emerging features.

Indexed as

coagulopathycoronavirusCOVID-19factor XaSARS-CoV-2thrombinvariantsviral evolution

Identifiers

PMID35734085
PMCPMC9216717
OpenAlexW4283016813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.