Evidence map›Paper›PMID 35734072›Full record

ArticleLaryngoscope investigative otolaryngology2022

Study on the chemotherapeutic effect and mechanism of cucurbitacin E on laryngeal cancer stem cells.

Xuelian Jiang, Binjuan Ma, Xudong Wei, Xiaoyan Xu, Jiyan Cao, Jingyue Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Phytochemicals Target Multiple Metabolic Pathways in Cancer.Antioxidants (Basel, Switzerland) · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xuelian JiangThe first school of Clinical Medicine lanzhou university Lanzhou China.ORCID https://orcid.org/0000-0003-2062-3291
Binjuan MaDepartment of E.N.T. Gansu Provincial Hospital Lanzhou China.
Xudong WeiThe first school of Clinical Medicine lanzhou university Lanzhou China.
Xiaoyan XuThe First School of Clinical Medicine Gansu University of Chinese Medicine Lanzhou China.
Jiyan CaoNingxia Medical University Ningxia China.
Jingyue ZhangThe first school of Clinical Medicine lanzhou university Lanzhou China.
First Hospital of Lanzhou University · CNGansu University of Traditional Chinese Medicine · CNGansu Provincial Hospital · CNNingxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Study on the chemotherapeutic effect and mechanism of cucurbitacin E (CuE) on laryngeal cancer stem cells. Methods: We used flow cytometry to sort out CD133 Results: CuE reduced the survival rate, proliferation ability, and migration ability of laryngeal cancer stem cells in vitro, and that CuE had a chemotherapeutic potentiating effect on doxorubicin. The possible mechanism of the chemotherapeutic effect of CuE was to reduce the expression of c-MYC protein, and the possible mechanism of chemotherapy synergy was to reduce the expression of ABCG2 and P-gp protein. Conclusion: CuE has a chemotherapeutic effect on laryngeal cancer stem cells, as well as a chemotherapy synergy.

Indexed as

ABCG2CD133c‐MYCcucurbitacin Elaryngeal cancer stem cellsP‐gp

Identifiers

PMID35734072
PMCPMC9195038
OpenAlexW4221100474

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.