Evidence map›Paper›PMID 35733879›Full record

ArticleDigital health

A virtual reality-based mind-body approach to downregulate psychophysiological arousal in adolescent insomnia.

Massimiliano de Zambotti, Dilara Yuksel, Orsolya Kiss, Giacinto Barresi, Nicole Arra, Laila Volpe, Christopher King, Fiona C Baker

Open access · goldAbstract read
In one paragraph

Article in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Insomnia disorder.Nature reviews. Disease primers · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Massimiliano de ZambottiCenter for Health Sciences, SRI International, Menlo Park, CA, USA.ORCID https://orcid.org/0000-0002-0057-5977
Dilara YukselCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
Orsolya KissCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
Giacinto BarresiRehab Technologies, Istituto Italiano di Tecnologia, Genoa, Italy.
Nicole ArraCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
Laila VolpeCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
Christopher KingDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Fiona C BakerCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
SRI International · USCincinnati Children's Hospital Medical Center · USItalian Institute of Technology · IT

Funding

Sleep and Cardiovascular Health in AdolescenceR01HL139652 · NHLBI · SRI INTERNATIONAL · PI DE ZAMBOTTI, MASSIMILIANO · 2018 to 2021
$2.9M
NHLBI NIH HHS R01 HL139652
6 · The paper itself

Abstract

Objective: In this study, we describe the rationale, supported by preliminary data, for a novel, digital, immersive virtual reality (VR)-based mind-body approach, designed to reduce bedtime arousal in adolescents with insomnia. Methods: Fifty-two high-school students (16-20 years; 32 female) with ( Results: The intervention resulted in acute autonomic and cortical modulation ( Conclusions: The study provides supporting preliminary evidence for the mechanism behind a novel VR-based digital approach, designed to regulate psychophysiological arousal levels by acting on neurocognitive and autonomic pathways. Further studies (e.g. randomized clinical trials) are needed to evaluate the isolated and synergistic effects of its components (e.g. VR vs. VR + paced breathing), and its efficacy, acceptance, and feasibility in alleviating insomnia symptoms in adolescents.

Indexed as

adolescencehyperarousalinsomniamind–bodypaced breathingvirtual reality

Identifiers

PMID35733879
PMCPMC9208061
OpenAlexW4283364960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.