ArticleRSC advances2022
Study and application of graphene oxide in the synthesis of 2,3-disubstituted quinolines
Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Recent Advancements in Metal-Free Carbon-Based Catalysts: A Challenge in Sustainable Fine Chemical Synthesis.Nanomaterials (Basel, Switzerland) · 2026Review
- Fabrication of a novel graphene oxide based magnetic nanocomposite and its usage as a highly effectual catalyst for the construction ofRSC advances · 2024Article
- Functionalized graphene oxide by 4-amino-3-hydroxy-1-naphthalenesulfonic acid as a heterogeneous nanocatalyst for the one-pot synthesis of tetraketone and tetrahydrobenzo[Nanoscale advances · 2024Article
- Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light.Beilstein journal of organic chemistry · 2024Article
- Synthesis of symmetric bis-α-ketoamides from renewable starting materials and comparative study of their nucleating efficiency in PLLA.RSC advances · 2023Article
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Authors and funding
7 authors.
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Abstract
The carbocatalyzed synthesis of 2,3-disubstituted quinolines is disclosed. This process involved a three-component Povarov reaction of anilines, aldehydes and electron-enriched enol ethers, which gave the substrate for the subsequent oxidation. Graphene oxide (GO) was exploited as a heterogeneous, metal-free and sustainable catalyst for both transformations. The multicomponent reaction proceeded under simple and mild reaction conditions, exhibited good functional group tolerance, and could be easily scaled up to the gram level. A selection of tetrahydroquinolines obtained was subsequently aromatized to quinolines. The multistep synthesis could also be performed as a one-pot procedure. Investigation of the real active sites of GO was carried out by performing control experiments and a by full characterization of the carbon material by X-ray photoelectron spectroscopy (XPS) and solid-state nuclear magnetic resonance (ssNMR).
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