ArticleNetwork neuroscience (Cambridge, Mass.)2022
Structure-function coupling as a correlate and potential biomarker of cognitive impairment in multiple sclerosis.
Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Functional Connectivity at Rest and During Cognitive Processing in Multiple Sclerosis: A Pilot Magnetoencephalography Study and Systematic Review.Brain sciences · 2026Article
- Structure-Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS.Annals of clinical and translational neurology · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Structure-function multilayer network integration and cognition in multiple sclerosis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Clinically Relevant Patterns of Co-Fluctuating Structure and Function in Multiple Sclerosis.European journal of neurology · 2025Article
- Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders.Brain : a journal of neurology · 2025Review
- Gait instability is a more specific predictor of corticospinal tract function than gait speed in clinically stable multiple sclerosis.Scientific reports · 2025Article
- The overgrowth of structure-function coupling in premature brain during infancy.Developmental cognitive neuroscience · 2025Article
- Counterfactual explanations of tree based ensemble models for brain disease analysis with structure function coupling.Scientific reports · 2025Article
- More Than the Sum of Its Parts: Disrupted Core Periphery of Multiplex Brain Networks in Multiple Sclerosis.Human brain mapping · 2025Article
- Elevated Activity in Left Homologous Music Circuits Is Inhibitory for Music Perception but Mediated by Structure-Function Coupling.CNS neuroscience & therapeutics · 2024Article
- Energy Associated With Dynamic Network Changes in Patients With Multiple Sclerosis and Cognitive Impairment.Neurology · 2024Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Linking structural and functional changes during aging using multilayer brain network analysis.Communications biology · 2024Article
- Cortical structural and functional coupling during development and implications for attention deficit hyperactivity disorder.Translational psychiatry · 2023Article
- Using graph theory as a common language to combine neural structure and function in models of healthy cognitive performance.Human brain mapping · 2023Article
- Naoxin'an capsules protect brain function and structure in patients with vascular cognitive impairment.Frontiers in pharmacology · 2023Article
- Editorial: Focus feature on biomarkers in network neuroscience.Network neuroscience (Cambridge, Mass.) · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) features extensive connectivity changes, but how structural and functional connectivity relate, and whether this relation could be a useful biomarker for cognitive impairment in MS is unclear. This study included 79 MS patients and 40 healthy controls (HCs). Patients were classified as cognitively impaired (CI) or cognitively preserved (CP). Structural connectivity was determined using diffusion MRI and functional connectivity using resting-state magnetoencephalography (MEG) data (theta, alpha1, and alpha2 bands). Structure-function coupling was assessed by correlating modalities, and further explored in frequency bands that significantly correlated with whole-brain structural connectivity. Functional correlates of short- and long-range structural connections (based on tract length) were then specifically assessed. Receiving operating curve analyses were performed on coupling values to identify biomarker potential. Only the theta band showed significant correlations between whole-brain structural and functional connectivity (rho = -0.26,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.