ArticleNetwork neuroscience (Cambridge, Mass.)2022
Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.
Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy.Epilepsia open · 2026Article
- Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment.Neuroimage. Reports · 2026Article
- Normative structural connectome constrains spreading transient brain activity in generalized epilepsy.BMC medicine · 2025Article
- Unlocking the Potential of Freeze-Dried Broccoli Powder: A Novel Approach to Enhancing Cognitive Resilience in Temporal Lobe Epilepsy.Food science & nutrition · 2025Article
- Temporal Lobe Epilepsy Perturbs the Brain-Wide Excitation-Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Morphometric network-based abnormalities correlate with psychiatric comorbidities and gene expression in PCDH19-related developmental and epileptic encephalopathy.Translational psychiatry · 2024Article
- Article
- Multi-scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI.Human brain mapping · 2023Article
- Editorial: Focus feature on biomarkers in network neuroscience.Network neuroscience (Cambridge, Mass.) · 2022Article
- Correction to: Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is one of the most common chronic neurological conditions, traditionally defined as a disorder of recurrent seizures. Cognitive and affective dysfunction are increasingly recognized as core disease dimensions and can affect patient well-being, sometimes more than the seizures themselves. Connectome-based approaches hold immense promise for revealing mechanisms that contribute to dysfunction and to identify biomarkers. Our review discusses emerging multimodal neuroimaging and connectomics studies that highlight network substrates of cognitive/affective dysfunction in the common epilepsies. We first discuss work in drug-resistant epilepsy syndromes, that is, temporal lobe epilepsy, related to mesiotemporal sclerosis (TLE), and extratemporal epilepsy (ETE), related to malformations of cortical development. While these are traditionally conceptualized as 'focal' epilepsies, many patients present with broad structural and functional anomalies. Moreover, the extent of distributed changes contributes to difficulties in multiple cognitive domains as well as affective-behavioral challenges. We also review work in idiopathic generalized epilepsy (IGE), a subset of generalized epilepsy syndromes that involve subcortico-cortical circuits. Overall, neuroimaging and network neuroscience studies point to both shared and syndrome-specific connectome signatures of dysfunction across TLE, ETE, and IGE. Lastly, we point to current gaps in the literature and formulate recommendations for future research.
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