Evidence map›Paper›PMID 35733420›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2022

Latent functional connectivity underlying multiple brain states.

Ethan M McCormick, Katelyn L Arnemann, Takuya Ito, Stephen José Hanson, Michael W Cole

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  3. Article
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  5. Article
  6. Article
  7. Article
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  9. Article
  10. The Prediction of Brain Activity from Connectivity: Advances and Applications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. An information-theoretic analysis of resting-state versus task fMRI.Network neuroscience (Cambridge, Mass.) · 2023
    Article
  19. Article
  20. Improving power in functional magnetic resonance imaging by moving beyond cluster-level inference.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ethan M McCormickCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.ORCID https://orcid.org/0000-0002-7919-4340
Katelyn L ArnemannCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.ORCID https://orcid.org/0000-0003-0454-0592
Takuya ItoCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.ORCID https://orcid.org/0000-0002-2060-4608
Stephen José HansonRutgers University Brain Imaging Center, Newark, NJ, USA.ORCID https://orcid.org/0000-0003-1985-2054
Michael W ColeCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.ORCID https://orcid.org/0000-0003-4329-438X

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Brain Network Mechanisms of Aging-Related Cognitive DeclineR01AG055556 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2017 to 2022
$2.3M
Brain Network Mechanisms of Instructed LearningR01MH109520 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2016 to 2020
$2.0M
NIA NIH HHS R01 AG055556NIMH NIH HHS R01 MH109520NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Functional connectivity (FC) studies have predominantly focused on resting state, where ongoing dynamics are thought to reflect the brain's intrinsic network architecture, which is thought to be broadly relevant because it persists across brain states (i.e., is state-general). However, it is unknown whether resting state is the optimal state for measuring intrinsic FC. We propose that latent FC, reflecting shared connectivity patterns across many brain states, better captures state-general intrinsic FC relative to measures derived from resting state alone. We estimated latent FC independently for each connection using leave-one-task-out factor analysis in seven highly distinct task states (24 conditions) and resting state using fMRI data from the Human Connectome Project. Compared with resting-state connectivity, latent FC improves generalization to held-out brain states, better explaining patterns of connectivity and task-evoked activation. We also found that latent connectivity improved prediction of behavior outside the scanner, indexed by the general intelligence factor (

Indexed as

ActFlowFactor analysisIntrinsic connectivityResting stateTask connectivity

Identifiers

PMID35733420
PMCPMC9208020

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.