Evidence map›Paper›PMID 35733350›Full record

ArticleNeuropsychopharmacology reports2022

Effect of CNTNAP2 polymorphism on receptive language in children with autism spectrum disorder without language developmental delay.

Yuka Shiota, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Sumie Iwasaki, Masuhiko Sano, Kyung-Min An, Shigeru Yokoyama, Mitsuru Kikuchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Yuka ShiotaUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Kanazawa, Japan.
Tetsu HirosawaUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Kanazawa, Japan.ORCID 0000-0001-8710-5638
Yuko YoshimuraUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Kanazawa, Japan.
Sanae TanakaUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Kanazawa, Japan.
Chiaki HasegawaJapan Society for the Promotion of Science, Tokyo, Japan.
Sumie IwasakiJapan Society for the Promotion of Science, Tokyo, Japan.
Masuhiko SanoDepartment of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Kyung-Min AnResearch Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.
Shigeru YokoyamaUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Kanazawa, Japan.
Mitsuru KikuchiUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Kanazawa, Japan.
Kanazawa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe receptive language ability of individuals with autism spectrum disorder (ASD) seems to lag behind expressive language ability. Several autism-related genes may influence this developmental delay. Polymorphism of one such gene, namely, the contactin-associated protein-like 2 gene (CNTNAP2), affects receptive language in individuals with language delay. However, the association between CNTNAP2 polymorphism and receptive language in individuals with no language delay remains unclear.

methodsWe included 59 children with ASD and 57 children with typical development in this study and investigated this association using coarse-grained exact matching.

resultsWe present the first evidence of an association between CNTNAP2 rs2710102 (A-allele carrier) and reduced receptive language ability in children with ASD whose language development was not delayed. Similarly, among children with typical development, A-allele carriers had lower receptive language ability, but the difference was non-significant.

conclusionsIt is possible that the effect of rs2710102 on receptive language ability is larger in the presence of autism-related genes. Consequently, we speculate that the effect of rs2710102 on receptive language ability would be exerted in combination with other genes. These findings provide new insights into the genetic interactions between mutations associated with common language disorders and ASD and identify molecular mechanisms and risk alleles that contribute to receptive vocabulary. These findings also provide practical guidance in terms of providing candidate genetic markers that may provide opportunities for targeted early intervention to stratify risk and improve prognosis for poor receptive language development in children with ASD.

Indexed as

Autism Spectrum DisorderLanguage Development DisordersChildContactinsGenetic MarkersHumansLanguage DevelopmentMembrane ProteinsNerve Tissue ProteinsCNTNAP2 protein, humanContactinsGenetic MarkersMembrane ProteinsNerve Tissue Proteinsautism spectrum disorderCNTNAP2gene polymorphismlanguage delayreceptive language

Identifiers

PMID35733350
PMCPMC9515703
OpenAlexW4283324200

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.