ArticleProceedings of the National Academy of Sciences of the United States of America2022
Slow oscillations promote long-range effective communication: The key for memory consolidation in a broken-down network.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 34 citations in OpenAlex.
- Predictability of sleep slow oscillation emergence and spatial extent from pre-onset neural dynamics.Scientific reports · 2026Article
- Classifying Sleep Slow Oscillations in Low Density EEG.Neuroinformatics · 2026Article
- Sleep strengthens successor representations of learned sequences in humans.PLoS biology · 2026Article
- Microglial metabolic reprogramming drives the therapeutic effects of bavachinin on brain network function and memory in Alzheimer's disease.Frontiers in pharmacology · 2026Article
- Assessing sleep, cognition and overnight memory performance in neurotypically developing youth in a children's hospital.Frontiers in sleep · 2026Article
- Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.Frontiers in sleep · 2026Review
- A user's introduction to an algorithmic method to identify space-time profiles of sleep slow oscillations: dataset constraints, case-use examples, and open-source code.Sleep advances : a journal of the Sleep Research Society · 2026Article
- EEG entropy modulation as a biomarker of emotion regulation and resilience.IBRO neuroscience reports · 2025Review
- The Space-Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence.Journal of sleep research · 2025Article
- Article
- Offline consolidation mechanisms of the retrieval practice effect: an analysis based on EEG signal characteristics.NPJ science of learning · 2025Article
- Sleep Modulates Neural Timescales and Spatiotemporal Integration in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer's disease.Translational psychiatry · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025Review
- A visual paired associate learning (vPAL) paradigm to study memory consolidation during sleep.Journal of sleep research · 2024Article
- Article
- A classification-based generative approach to selective targeting of global slow oscillations during sleep.Frontiers in human neuroscience · 2024Article
- Elevating understanding: Linking high-altitude hypoxia to brain aging through EEG functional connectivity and spectral analyses.Network neuroscience (Cambridge, Mass.) · 2024Article
- Neural reactivation during human sleep.Emerging topics in life sciences · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A prominent and robust finding in cognitive neuroscience is the strengthening of memories during nonrapid eye movement (NREM) sleep, with slow oscillations (SOs;<1Hz) playing a critical role in systems-level consolidation. However, NREM generally shows a breakdown in connectivity and reduction of synaptic plasticity with increasing depth: a brain state seemingly unfavorable to memory consolidation. Here, we present an approach to address this apparent paradox that leverages an event-related causality measure to estimate directional information flow during NREM in epochs with and without SOs. Our results confirm that NREM is generally a state of dampened neural communication but reveals that SOs provide two windows of enhanced large-scale communication before and after the SO trough. These peaks in communication are significantly higher when SOs are coupled with sleep spindles compared with uncoupled SOs. To probe the functional relevance of these SO-selective peaks of information flow, we tested the temporal and topographic conditions that predict overnight episodic memory improvement. Our results show that global, long-range communication during SOs promotes sleep-dependent systems consolidation of episodic memories. A significant correlation between peaks of information flow and memory improvement lends predictive validity to our measurements of effective connectivity. In other words, we were able to predict memory improvement based on independent electrophysiological observations during sleep. This work introduces a noninvasive approach to understanding information processing during sleep and provides a mechanism for how systems-level brain communication can occur during an otherwise low connectivity sleep state. In short, SOs are a gating mechanism for large-scale neural communication, a necessary substrate for systems consolidation and long-term memory formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.