ArticleParasites & vectors2022
Mitochondrial phylogenomics provides insights into the taxonomy and phylogeny of fleas.
Article in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- The first complete mitochondrial genome sequences ofFrontiers in veterinary science · 2026Article
- Mitogenomic analysis ofFrontiers in veterinary science · 2026Article
- Morphological traits and mitogenome of Thaumapsylla breviceps orientalis endemic to China provide insight into the evolution of the order Siphonaptera.Scientific reports · 2025Article
- Highlighting zoonotic importance of synanthropic fleas through microbiome analysis.Scientific reports · 2025Article
- Impact factors and genetic characteristics of head lice infestation in schoolchildren: a cross-sectional study from 2018 to 2023 in central China.Parasites & vectors · 2025Article
- Chromosome-level genome assembly of the seasonally polyphenic scorpionfly (Panorpa liui).Scientific data · 2025Article
- Molecular characterization of the oriental cat flea,Current research in parasitology & vector-borne diseases · 2025Article
- Species Composition, Diversity, Abundance, and Phylogeny of Fleas of Small Mammals in Selected Plague-Endemic and Nonendemic Areas of Tanzania.Journal of parasitology research · 2025Article
- Mitogenomic architecture and phylogenetic placement ofFrontiers in veterinary science · 2025Article
- The complete mitochondrial genomes ofFrontiers in veterinary science · 2025Article
- Taxonomy and phylogeny of rodents parasitic fleas in southeastern China with description of a new subspecies of Ctenophthalmus breviprojiciens.Scientific reports · 2024Article
- The first mitogenome of the subfamily Stenoponiinae (Siphonaptera: Ctenophthalmidae) and implications for its phylogenetic position.Scientific reports · 2024Article
- The complete mitochondrial genome of the rodent flea Nosopsyllus laeviceps: genome description, comparative analysis, and phylogenetic implications.Parasites & vectors · 2024Article
- Flea Burden on Rodents and Its Associated Determinants in Plague-Endemic Localities of Karatu District, Tanzania: A Cross-Sectional Study.Public health challenges · 2024Article
- Comparative Morphology of the Wing Base Structure Illuminates Higher-Level Phylogeny of Holometabola.Insects · 2024Article
- Phylogeny and divergence time estimation of the subfamily Amphipsyllinae based on theFrontiers in veterinary science · 2024Article
- The fragmented mitochondrial genomes of twoiScience · 2023Article
- Metagenomics of culture isolates and insect tissue illuminate the evolution ofMicrobial genomics · 2023Article
- Complete mitochondrial genome ofFrontiers in veterinary science · 2023Article
- Analysis of complete mitogenomes and phylogenetic relationships ofFrontiers in veterinary science · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundFleas (Insecta: Siphonaptera) are obligatory hematophagous ectoparasites of humans and animals and serve as vectors of many disease-causing agents. Despite past and current research efforts on fleas due to their medical and veterinary importance, correct identification and robust phylogenetic analysis of these ectoparasites have often proved challenging.
methodsWe decoded the complete mitochondrial (mt) genome of the human flea Pulex irritans and nearly complete mt genome of the dog flea Ctenocephalides canis, and subsequently used this information to reconstruct the phylogeny of fleas among Endopterygota insects.
resultsThe complete mt genome of P. irritans was 20,337 bp, whereas the clearly sequenced coding region of the C. canis mt genome was 15,609 bp. Both mt genomes were found to contain 37 genes, including 13 protein-coding genes, 22 transfer RNA genes and two ribosomal RNA genes. The coding region of the C. canis mt genome was only 93.5% identical to that of the cat flea C. felis, unequivocally confirming that they are distinct species. Our phylogenomic analyses of the mt genomes showed a sister relationship between the order Siphonaptera and orders Diptera + Mecoptera + Megaloptera + Neuroptera and positively support the hypothesis that the fleas in the order Siphonaptera are monophyletic.
conclusionsOur results demonstrate that the mt genomes of P. irritans and C. canis are different. The phylogenetic tree shows that fleas are monophyletic and strongly support an order-level objective. These mt genomes provide novel molecular markers for studying the taxonomy and phylogeny of fleas in the future.
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