Evidence map›Paper›PMID 35733159›Full record

ArticleBMC veterinary research2022

Evaluation of safety and anti-obesity effects of DWP16001 in naturally obese dogs.

Beomseok Rhee, Rahman Md Mahbubur, Changfan Jin, Ji-Soo Choi, Hyun-Woo Lim, Wan Huh, Joon Seok Park, Jumi Han, Sokho Kim, Youngwon Lee and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Beomseok RheeKNOTUS Co., Ltd., Research Center, Incheon, Republic of Korea.
Rahman Md MahbuburKNOTUS Co., Ltd., Research Center, Incheon, Republic of Korea.
Changfan JinKNOTUS Co., Ltd., Research Center, Incheon, Republic of Korea.
Ji-Soo ChoiDaewoong Pharmaceutical Co., Ltd., Yongin, Republic of Korea.
Hyun-Woo LimDaewoong Pharmaceutical Co., Ltd., Yongin, Republic of Korea.
Wan HuhDaewoong Pharmaceutical Co., Ltd., Yongin, Republic of Korea.
Joon Seok ParkDaewoong Pharmaceutical Co., Ltd., Yongin, Republic of Korea.
Jumi HanDaewoong Pharmaceutical Co., Ltd., Yongin, Republic of Korea.
Sokho KimKNOTUS Co., Ltd., Research Center, Incheon, Republic of Korea.
Youngwon LeeDepartment of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Jinho ParkDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea. jpark@jbnu.ac.kr.
Daewoong Pharmaceutical (South Korea) · KRChungnam National University · KRJeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate the anti-obesity effects of DWP16001, a sodium-glucose cotransporter-2 (SGLT2 inhibitor), in naturally obese dogs. A total of 20 dogs were divided into four equal groups: one obese control (OC group), and three treated groups; DWP0.2 group, DWP0.5 group, and DWP1 group. OC group fed with food for maintenance and treated groups were fed with food for maintenance with 0.2 mg/kg DWP16001, 0.5 mg/kg DWP16001 and 1 mg/kg DWP16001, respectively. The food for maintenance was provided to dogs as 2 RER (Resting energy requirement) in kcal and DWP16001-supplemented food was administered once a day for 8 weeks.

resultsBody condition score, body weight, and fat thickness were significantly reduced (P < 0.05) in the DWP0.2 group compared with the OC group, respectively without affecting the food consumption. At the 10

conclusionsThe above results and discussion suggest that DWP16001 is safe and might have anti-obesity effects in naturally obese dogs.

Indexed as

Dog DiseasesObesityAnimalsBlood GlucoseBody WeightDogsInsulinTriglyceridesBlood GlucoseInsulinTriglyceridesDogsDWP16001ObesitySGLT2 inhibitor

Identifiers

PMID35733159
PMCPMC9214997
OpenAlexW4283264426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.