Evidence map›Paper›PMID 35733158›Full record

ReviewGut pathogens2022

The emerging role of neutrophilic extracellular traps in intestinal disease.

Feng Chen, Yongqiang Liu, Yajing Shi, Jianmin Zhang, Xin Liu, Zhenzhen Liu, Jipeng Lv, Yufang Leng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut pathogens, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Feng ChenThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Yongqiang LiuThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Yajing ShiThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Jianmin ZhangThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Xin LiuThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Zhenzhen LiuThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Jipeng LvThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Yufang LengThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. lengyf@lzu.edu.cn.ORCID http://orcid.org/0000-0001-7094-2413
Lanzhou University · CNFirst Hospital of Lanzhou University · CN

Funding

National Natural Science Foundation of China 81960345Natural Science Foundation of Gansu Province 21JR1RA069
6 · The paper itself

Abstract

Neutrophil extracellular traps (NETs) are extracellular reticular fibrillar structures composed of DNA, histones, granulins and cytoplasmic proteins that are delivered externally by neutrophils in response to stimulation with various types of microorganisms, cytokines and host molecules, etc. NET formation has been extensively demonstrated to trap, immobilize, inactivate and kill invading microorganisms and acts as a form of innate response against pathogenic invasion. However, NETs are a double-edged sword. In the event of imbalance between NET formation and clearance, excessive NETs not only directly inflict tissue lesions, but also recruit pro-inflammatory cells or proteins that promote the release of inflammatory factors and magnify the inflammatory response further, driving the progression of many human diseases. The deleterious effects of excessive release of NETs on gut diseases are particularly crucial as NETs are more likely to be disrupted by neutrophils infiltrating the intestinal epithelium during intestinal disorders, leading to intestinal injury, and in addition, NETs and their relevant molecules are capable of directly triggering the death of intestinal epithelial cells. Within this context, a large number of NETs have been reported in several intestinal diseases, including intestinal infections, inflammatory bowel disease, intestinal ischemia-reperfusion injury, sepsis, necrotizing enterocolitis, and colorectal cancer. Therefore, the formation of NET would have to be strictly monitored to prevent their mediated tissue damage. In this review, we summarize the latest knowledge on the formation mechanisms of NETs and their pathophysiological roles in a variety of intestinal diseases, with the aim of providing an essential directional guidance and theoretical basis for clinical interventions in the exploration of mechanisms underlying NETs and targeted therapies.

Indexed as

ColitisColorectal neoplasmsInfectionInflammationIntestinal diseasesNeutrophil extracellular trapsNeutrophilsTherapeutics

Identifiers

PMID35733158
PMCPMC9214684
OpenAlexW4283265333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.