ArticleReproductive health2022
Diagnostic value of a single β-hCG test in predicting reproductive outcomes in women undergoing cleavage embryo transfer: a retrospective analysis from a single center.
Article in Reproductive health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- When to test: defining the earliest reliable time for pregnancy detection and its prognostic value after frozen embryo transfer.AJOG global reports · 2026Article
- Predicting of early miscarriage based on machine learning: a retrospective cohort study in China.BMC pregnancy and childbirth · 2026Article
- Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Tailoring clinical management after embryo transfer using β-hCG levels in resource-limited settings.Scientific reports · 2025Article
- Serum β-hCG, AMH, TSH, and PRL Levels in Predicting the Outcome of Early Pregnancy 14 Days after Embryo Transfer: A Prospective Cohort Study.Advanced biomedical research · 2025Article
- An individualized risk prediction tool for ectopic pregnancy within the first 10 weeks of gestation based on machine learning algorithms.Frontiers in medicine · 2025Article
- Is the Human Chorionic Gonadotropin Level on Day 10 After Cleaved Embryo Transfer a Predictor of Perinatal Outcome?: A Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The relationship between serum levels of epidermal growth factor and β-human chorionic gonadotropin and the type and prognosis of ectopic pregnancy.Archives of gynecology and obstetrics · 2024Article
- Combined analysis of estradiol and β-hCG to predict the early pregnancy outcome of FET: a retrospective study.Journal of ovarian research · 2024Article
- Predictive value of placental growth factor level for adverse pregnancy outcome in twin pregnancies at advanced maternal age.American journal of translational research · 2024Article
- Comparisons of conventional in vitro fertilization versus intracytoplasmic sperm injection in women with thyroid autoimmunity and non-male factor infertility, a propensity score matching analysis.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe present study investigated the role of β-hCG in predicting reproductive outcomes and established optimal β-hCG cutoff values in women undergoing cleavage embryo transfer.
methodsThe patients were transferred with fresh or frozen-thawed embryos and had serum β-hCG levels tested on the 14th day post-embryo transfer. Serum β-hCG levels were compared between different groups. Different cutoff values of β-hCG were established and used to divide the patients into different groups. Reproductive outcomes between groups based on β-hCG levels were compared.
resultsSignificant discrepancies in general characteristics were observed in the subgroups. The cutoff values of β-hCG for predicting the presence/absence of pregnancy, biochemical pregnancy/clinical pregnancy, presence/absence of adverse pregnancy outcomes, and singleton/twin live birth in the cleavage groups were 89.6, 241.1, 585.9, and 981.1 mIU/L, respectively. Biochemical pregnancy rates and adverse pregnancy outcome rates significantly decreased from the low β-hCG group to the higher β-hCG group in sequence. Significantly higher full-term live birth rates were observed in the highest β-hCG group (P < 0.001).
conclusionSerum β-hCG levels were strongly associated with reproductive outcomes. However, the interpretation of β-hCG levels must consider the number and quality of embryos and transfer protocols. When β-hCG was tested on a fixed day post-ET, different cutoff values were required for the prediction of early clinical outcomes. The association between β-hCG and obstetric outcomes must be investigated.
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