ArticleBMC pregnancy and childbirth2022
Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis.
Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Maternal childhood adversity as an upstream vulnerability for prenatal alcohol use and maternal mental health.Alcohol, clinical & experimental research · 2026Article
- Multiple Adverse Childhood Experiences and Maternal Mental Health Outcomes Among Kenyan Mothers With and Without HIV.AIDS and behavior · 2026Article
- Prematurity and Multidimensional Risk Patterns in Adolescent and Adult Pregnancies: A Principal Component Analysis in an Eastern European Cohort.Children (Basel, Switzerland) · 2025Article
- Patterns of Adverse Childhood Experiences and Postpartum Depressive Symptoms.Journal of child & adolescent trauma · 2025Article
- Stress during puberty and adulthood pregnancy impact histone acetylation regulators in the hypothalamus.Neuroscience · 2025Article
- Associations Between Adverse Childhood Experiences and Prenatal Mental Health in the French EDEN Cohort: Cumulative, Person-Centered, and Dimensional Approaches.Depression and anxiety · 2025Article
- Do the Effects of Head Start Vary Across Time Based on Children's Exposure to Different Patterns of Childhood Adversity? Differential Intervention Effects Using Latent Profile Analysis and Time-varying Effect Modeling.Children and youth services review · 2024Article
- Multiple Risk in Pregnancy- Prenatal Risk Constellations and Mother-Infant Interactions, Parenting Stress, and Child Externalizing and Internalizing Behaviors: A Prospective Longitudinal Cohort Study from Pregnancy to 18 Months Postpartum.Research on child and adolescent psychopathology · 2024Article
- Patterns of maternal adverse childhood experiences and the intergenerational association of preschool children's emotional and behavioral problems.Frontiers in psychiatry · 2024Article
- Latent profiles of childhood psychological maltreatment and their links to adult mental health in China and the UK.Child and adolescent psychiatry and mental health · 2023Article
- Associations between adverse childhood experiences and perinatal outcomes.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
23 authors at 13 institutions in 11 countries.
Funding
Abstract
backgroundThis paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs).
methodsA total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed.
resultsThree high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes.
conclusionOur results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges.
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