Evidence map›Paper›PMID 35733052›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

An In Vivo Mouse Model to Study Blood-Brain Barrier Destabilization in the Chronic Phase of Stroke.

Svetlana M Stamatovic, Chelsea M Phillips, Richard F Keep, Anuska V Andjelkovic

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Svetlana M StamatovicDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Chelsea M PhillipsGraduate Program in Neuroscience, University of Michigan Medical School, Ann Arbor, MI, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Anuska V AndjelkovicDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. anuskaa@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Connexin 43 and hemorrhagic complication in cerebral amyloid angiopathyRF1AG064957 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDJELKOVIC-ZOCHOWSKA, ANUSKA V. · 2019 to 2019
$2.3M
Influence of Brain Inflammation on the Occurrence of Embolic StrokeR21NS098211 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STAMATOVIC, SVETLANA M · 2016 to 2017
$421k
NIA NIH HHS RF1 AG064957NINDS NIH HHS R21 NS098211NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Cerebral ischemic injury evokes a complex cascade of pathophysiological events at the blood-vascular-parenchymal interface. These evolve over time and space and result in progressive neurological damage. Emerging evidence suggests that blood-brain barrier (BBB) recovery and reestablishment of BBB impermeability are incomplete and that these could influence stroke injury recovery, increase the risk of new stroke occurrence, and be a solid substrate for developing vascular dementia. Recent work from the author's laboratory has established the existence of incomplete BBB recovery in chronic stroke conditions that was induced by structural alterations to brain endothelial junctional complexes and persistent BBB leakage. The experimental methodology presented here is focused on modelling chronic stroke injury using an in vivo thromboembolic mouse stroke model and how to evaluate the kinetics and magnitude of BBB hyperpermeability in chronic stroke conditions using a combination of magnetic resonance imaging, tracer studies, and immunohistochemistry.

Indexed as

Brain IschemiaStrokeAnimalsBiological TransportBlood-Brain BarrierBrainDisease Models, AnimalMiceBlood–brain barrierMagnetic resonance imagingPermeability assaysThromboembolic strokeTracers

Identifiers

PMID35733052
OpenAlexW4285229387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.