ArticleEuropean journal of pediatrics2022
Midazolam premedication in ileocolic intussusception: a retrospective multicenter study.
Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Determinants of ultrasound-guided reduction failure and pathological lead points in pediatric intussusception.Pediatric surgery international · 2026Article
- European society of paediatric radiology abdominal task force procedural recommendations for intussusception reduction: what's the evidence?Pediatric radiology · 2026Review
- Opioid Administration and Reduction of Pediatric Ileocolic Intussusception.JAMA network open · 2025Article
- Practice variation in the management of pediatric intussusception: a narrative review.European journal of pediatrics · 2024Review
- Intussusception reduction methods in daily practice-a survey by the European Society of Paediatric Radiology Abdominal Imaging Taskforce.Pediatric radiology · 2024Article
- Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception.JAMA network open · 2023Article
- Ketamine sedation during air enema reduction of pediatric intussusception: Assessing safety and intraluminal pressure.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ileocolic intussusception is a common cause of bowel obstruction. When spontaneous reduction does not occur, non-operative management through enema reduction is necessary. Despite the evidence indicating that sedatives favor success in the reduction, their use is still not a common practice. To determine if midazolam (MDZ) before enema improves the rate of procedure success, we retrospectively reviewed charts of patients admitted to two Italian pediatric emergency departments. Outcome measures were the success rate of the enema, recurrence, and need for surgery. Patients were grouped according to the use of MDZ or not, before hydrostatic reduction attempt. We included 69 and 37 patients in the MDZ and non-MDZ groups, respectively. The two groups did not differ in demographics, clinical characteristics, and ultrasound findings. Intussusception reduction after the first enema attempt occurred in 75% (MDZ group) and 32.4% (non-MDZ group) of patients (P < .001); 27.9% (MDZ group) and 77.8% (non-MDZ group) of patients underwent surgery (P < .001). Among them, spontaneous reduction of intussusception during the induction of general anesthesia occurred in 31.6% and 42.9% of patients, respectively (P .43). Multivariate logistic regression analysis showed that only MDZ had a positive effect on the result of the enema (OR 7.602, 95%CI 2.669-21.652, P < .001).
conclusionProcedural sedation with MDZ for enema reduction of intussusception can increase the success rate and lead to a better management of patients. WHAT IS KNOWN: • Despite the evidence of the usefulness of sedatives in the reduction of intussusception, their use is still not a common practice. WHAT IS NEW: • Midazolam during enema reduction of intussusception can increase the success rate and consequently lead to better management of patients.
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