Evidence map›Paper›PMID 35732972›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Imaging joint infections using D-methyl-

Ilona Polvoy, Youngho Seo, Matthew Parker, Megan Stewart, Khadija Siddiqua, Harrison S Manacsa, Vahid Ravanfar, Joseph Blecha, Thomas A Hope, Henry Vanbrocklin and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. DynamicAmerican journal of respiratory and critical care medicine · 2025
    Observational
  2. Development of NovelACS pharmacology & translational science · 2025
    Article
  3. d-[5-ACS infectious diseases · 2025
    Article
  4. Article
  5. Evaluation of [Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Biological Evaluation of d-[Journal of medicinal chemistry · 2024
    Article
  7. Pilot Evaluation of S-(3-[Molecular imaging and biology · 2024
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  15. Article
  16. Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [Journal of the American Chemical Society · 2023
    Article
  17. Metabolic kinetic modeling of [European journal of nuclear medicine and molecular imaging · 2023
    Article
  18. New Approaches for Imaging Bacteria.Seminars in nuclear medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Ilona PolvoyDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Matthew ParkerDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Megan StewartDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Khadija SiddiquaDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Harrison S ManacsaDepartment of Orthopedic Surgery, University of California, San Francisco, CA, USA.
Vahid RavanfarDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Joseph BlechaDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Thomas A HopeDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Henry VanbrocklinDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Jeffrey BarryDepartment of Orthopedic Surgery, University of California, San Francisco, CA, USA.
Erik HansenDepartment of Orthopedic Surgery, University of California, San Francisco, CA, USA.
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA.
Joanne EngelDepartment of Medicine, University of California, San Francisco, CA, USA.
Oren S RosenbergDepartment of Medicine, University of California, San Francisco, CA, USA.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA. david.m.wilson@ucsf.edu.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, 94107, USA. michael.ohliger@ucsf.edu.
Berry (United States) · USUniversity of California, San Francisco · USChan Zuckerberg Initiative (United States) · USSan Francisco General Hospital · USUniversity of California, Berkeley · US

Funding

Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Sensing living P. aeruginosa using D-alanine derived radiotracersR01EB030897 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N., OHLIGER, MICHAEL · 2021 to 2024
$2.7M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985NIBIB NIH HHS R01 EB030897
6 · The paper itself

Abstract

purposeNon-invasive imaging is a key clinical tool for detection and treatment monitoring of infections. Existing clinical imaging techniques are frequently unable to distinguish infection from tumors or sterile inflammation. This challenge is well-illustrated by prosthetic joint infections that often complicate joint replacements. D-methyl-

methods614.5 ± 100.2 MBq of D-

resultsD-

conclusionD-

Indexed as

MethioninePositron-Emission TomographyHumansMagnetic Resonance ImagingRadiometryTissue DistributionMethionineD-11C-MetMagnetic resonance imagingNuclear medicinePositron emission tomographyProsthetic joint infection

Identifiers

PMID35732972
PMCPMC9399217
OpenAlexW4283331509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.