Evidence map›Paper›PMID 35732957›Full record

ArticleJournal of neurology2022

Initial symptoms of vertebrobasilar artery occlusions and the outcomes after endovascular treatment.

Jinjing Wang, Shuanggen Zhu, Pengfei Xu, Xianjun Huang, Chaolai Liu, Dezhi Liu, Lulu Xiao, Mengmeng Gu, Qiankun Cai, Chunrong Tao and 6 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Jinjing Wang *Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, China.
Shuanggen Zhu *Department of Neurology, The Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, Guangdong, China.
Pengfei XuStroke Center & Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Xianjun HuangDepartment of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
Chaolai LiuDepartment of Neurology, The First People's Hospital of Jining, Jining, Shandong, China.
Dezhi LiuDepartment of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Lulu XiaoDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, China.
Mengmeng GuDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Qiankun CaiDepartment of Neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Chunrong TaoStroke Center & Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Shizhan LiDepartment of Neurology, The First People's Hospital of Yulin, Yulin, Guangxi, China.
Qizhang WangDepartment of Neurology, Shenzhen Shajing People's Hospital, Shenzhen, Guangdong, China.
Wenya LanDepartment of Cerebrovascular Disease Treatment Center, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.
Wen SunStroke Center & Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China. sunwen_medneuro@163.com.ORCID http://orcid.org/0000-0002-7268-2085
Xinfeng LiuDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, China. xfliu2@vip.163.com.
PERSIST Investigators
University of Science and Technology of China · CNNanjing General Hospital of Nanjing Military Command · CNFujian Medical University · CNGuangdong Medical College · CNJining First People's Hospital · CNNanjing Brain Hospital · CNNanjing Medical University · CNShanghai University of Traditional Chinese Medicine · CNShenZhen People’s Hospital · CNWannan Medical College · CN

Funding

National Natural Science Foundation of China 81870946National Natural Science Foundation of China 82001260National Natural Science Foundation of China U20A20357Sanming Project of Medicine in Shenzhen HLPM201907020102Sanming Project of Medicine in Shenzhen MKD202007090208University Natural Science Research Project of Anhui Province 2018085MH271University Natural Science Research Project of Anhui Province 202104j07020049
6 · The paper itself

Abstract

backgroundAcute vertebrobasilar artery occlusion (VBAO) is a devastating disease in stroke patients. This study was aimed to identify the initial symptoms of patients with acute VBAO receiving endovascular treatment and determine its associations with clinical outcomes.

methodsPatients with VBAO receiving endovascular treatment at 21 stroke centres in China were recruited for this derivation cohort A data-driven approach of latent class analysis was applied to identify distinct symptom typologies of VBAO patients. Multivariable binary and ordinary logistic regressions were used to evaluate the associations between symptom subtypes and clinical outcomes.

resultsA total of 548 patients were analysed in this study. Four distinct subgroups were defined: the vestibular symptom group (32.8%), anterior circulation mimic group (26.5%), non-specific symptom group (14.8%) and severe VBAO symptom group (25.9%). Compared with severe VBAO symptoms, non-specific symptoms were independently associated with higher rates of favourable outcome and functional independence at the 3 months [odds ratio (OR) 2.46, 95% confidence interval (CI) 1.15-5.28; OR 3.46, 95% CI 1.54-7.79]and 1 year follow-up (OR 2.25, 95% CI 1.05-4.82; OR 2.69, 95% CI 1.22-5.92), and better functional improvement (shift in mRS score) at the 3 months (OR 2.05, 95% CI 1.15-3.67).

conclusionWe identified four distinctive subtypes based on the initial symptoms of VBAO patients. Severe VBAO symptoms were associated with poor outcomes while non-specific and vestibular symptoms were indicators of a favourable outcome.

Indexed as

Arterial Occlusive DiseasesEndovascular ProceduresStrokeVertebrobasilar InsufficiencyArteriesHumansRetrospective StudiesThrombectomyTreatment OutcomeEndovascular treatmentInitial symptomsOutcomesVertebrobasilar artery occlusions

Identifiers

PMID35732957
OpenAlexW4283260609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.