ArticleProstate cancer and prostatic diseases2023
Predictive role of node-rads score in patients with prostate cancer candidates for radical prostatectomy with extended lymph node dissection: comparative analysis with validated nomograms.
Article in Prostate cancer and prostatic diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Diagnostic accuracy of node-RADS for the detection of lymph node invasion: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Node-RADS: a systematic review and meta-analysis of diagnostic performance, category-wise malignancy rates, and inter-observer reliability.European radiology · 2025Pooled it
- Application of radiomics-based prediction model to predict preoperative lymph node metastasis in prostate cancer: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- The predictive value of machine learning and nomograms for lymph node metastasis of prostate cancer: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2023Pooled it
- CT-based Node-RADS for evaluating regional lymph node metastasis and postoperative recurrence in patients with pancreatic ductal adenocarcinoma undergoing upfront surgery.European radiology · 2026Article
- Assessment of inter-reader agreement and diagnostic performance of Node-RADS in colon cancer.Insights into imaging · 2026Article
- A head-to-head comparison of MRI and CT using Node-RADS for rectal cancer lymph nodes: Observer agreement and diagnostic performance.European journal of radiology open · 2026Article
- Multireader diagnostic performance of MRI-based Node-RADS for pelvic lymph node metastasis in endometrial carcinoma.European radiology · 2026Article
- Prognostic value of Node-RADS scoring in stage IIICr cervical cancer: development and validation of novel nomograms.Insights into imaging · 2026Article
- Diagnostic performance of Node-RADS on MRI for a standardized assessment of lymph node metastasis in ovarian cancer.Abdominal radiology (New York) · 2026Article
- Diagnostic performance of CT-based node reporting and data system (Node-RADS) for regional lymph node metastasis in periampullary cancer.Abdominal radiology (New York) · 2026Article
- An improved diagnostic criterion based on Node-RADS MRI score for lymph node metastasis in papillary thyroid carcinoma.Quantitative imaging in medicine and surgery · 2026Article
- Predictive value of node-RADS scoring system for axillary lymph node metastasis in breast cancer.BMC medical imaging · 2026Article
- Standardizing cervical lymph node evaluation in papillary thyroid carcinoma: diagnostic accuracy of Node-RADS on ultrasound.Frontiers in endocrinology · 2026Article
- Utility of node-RADS in preoperatively detecting pelvic lymph node metastasis in bladder cancer.World journal of urology · 2025Article
- Latest Advancements and Future Directions in Prostate Cancer Surgery: Reducing Invasiveness and Expanding Indications.Cancers · 2025Review
- Article
- Validation of the Node Reporting and Data System (Node-RADS) for standardized CT evaluation of regional lymph nodes in esophageal squamous cell carcinoma patients.European radiology · 2025Article
- Node Reporting and Data System 1.0 (Node-RADS) for the Assessment of Oncological Patients' Lymph Nodes in Clinical Imaging.Journal of clinical medicine · 2025Review
- Diagnostic performance of Node-RADS score for mesorectal lymph node metastasis in rectal cancer.Abdominal radiology (New York) · 2025Article
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21 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe Reporting and Data System (RADS) have been used in the attempts to standardize the results of oncological scans in different scenarios, such as lymph nodes, adding configuration criteria to size determination. We analyze the predictive value of preoperative Node-RADS determination at imaging for pelvic lymph node (PLN) involvement in cases of prostate cancer (PC) considered for radical prostatectomy (RP) with extended lymph node dissection (eLND) and we compare it with validate predictive nomograms (MSKCC, Briganti and Gandaglia).
methods150 patients with a histological diagnosis of PC (high risk or intermediate with an estimated risk for pN+ higher than 5% using the Briganti or 7% using the Gandaglia nomogram) submitted for RP with an ePLND from 2018 and 2021 were retrospectively examined. Node-RADS determination was performed in all cases using the preoperative magnetic resonance (MR), performed by a radiologist blinded for pathologic results and compared with the MSKCC, Briganti 2012, Gandaglia 2017 and Gandaglia 2019 nomograms.
resultsPLN involvement at final pathology (pN+) was found in 36/150 (24.0%) of cases and the mean percentage of positive LNs in pN+ cases was 15.90 ± 13.40. The mean number of PLNs removed at RP was similar (p = 0.188) between pN0 (23.9 ± 8.0) and pN+ (25.3 ± 8.0) cases. Considering a Node RADS 4-5 positive and a Node RADS 1-2 negative, the PPV was 100% and the NPV was 79.6%. A Node RADS score 4-5 showed a lower sensitivity (0.167 versus 0.972, 1.000, 0.971, 0.960 respectively), a higher specificity (1.000 versus 0.079, 0.096, 0.138, 0.186 respectively) and a similar AUC (0.583 versus 0.591, 0.581, 0.574, 0.597 respectively) when compared to MSKCC, Briganti 2012, Gandaglia 2017 and Gandaglia 2019 nomograms.
conclusionsOur evaluation suggests that Node RADS score, combining configuration criteria to size determination could improve specificity in terms of pathologic PLN prediction but a very low sensitivity has been also described.
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