ArticleNature2022
Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 84 citations in OpenAlex.
- Clonal CD8 T cells link peripheral and intrathecal immunity in ALS4 progression: a multiomics reference for ALS.Research square · 2026Article
- Review
- Multi-hit genetic lesions and a stress-imprinted immune transcriptome define the inflammatory pathology in ALS patients.Research square · 2026Article
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Adaptive immunity in the pathogenesis of neurodegeneration.Nature immunology · 2026Review
- Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming.Nature neuroscience · 2026Article
- Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8Journal of neuroinflammation · 2026Article
- Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8bioRxiv : the preprint server for biology · 2026Article
- ERVK activity in CD8Journal of neuroinflammation · 2026Article
- CD8Science China. Life sciences · 2026Review
- Immune signaling and function in neurodegeneration.The Journal of clinical investigation · 2026Review
- Motor neuron disease can present as a paraneoplastic neurologic syndrome with various phenotypes.Brain communications · 2026Article
- Article
- Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity.Research square · 2025Article
- Altered T-cell reactivity in the early stages of Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement.Research square · 2025Article
- Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement.medRxiv : the preprint server for health sciences · 2025Article
- TDP-43 pathology induces CD8bioRxiv : the preprint server for biology · 2025Article
- Granzyme KNature immunology · 2025Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 9 institutions in 3 countries.
Laura CampisiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. laura.campisi@mssm.edu.ORCID 0000-0003-4173-4521
Shahab ChizariDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5659-1140
Jessica S Y HoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-2234-2602
Anastasia GromovaDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Frederick J ArnoldDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-1927-264X
Lorena MoscaMedical Genetics Unit, Department of Laboratory Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Xueyan MeiBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yesai FstkchyanDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Denis TorreDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cindy BeharryDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marta Garcia-FornSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miguel Jiménez-AlcázarSeve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain.
Vlad A. KorbenDepartment of Pathology and Cell Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-9127-292X
Jack PrazichDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Zahi A FayadBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3439-7347
Marcus M SeldinDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA.
Silvia De RubeisSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9383-6883
Craig L BennettDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Lyle W OstrowNeuromuscular Division of the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7158-5243
Christian LunettaNEMO Clinical Center, Fondazione Serena Onlus, Milan, Italy.
Massimo SquatritoSeve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain.
Minji ByunDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neil A ShneiderDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA.
Ning JiangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1103-5922
Albert R La SpadaDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu.
Ivan MarazziDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu.ORCID 0000-0003-3376-0922
Icahn School of Medicine at Mount Sinai · USUniversity of California, Irvine · USUniversity of Pennsylvania · USAllen Institute for Brain Science · USColumbia University · USSpanish National Cancer Research Centre · ESAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITIstituti Clinici Scientifici Maugeri · ITJohns Hopkins University · US
Funding
TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5MTraining in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6MLa Spada Outstanding Investigator AwardR35NS122140 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ALBERT R LA SPADA · 2021 to 2026
$7.2MDynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8MMicroglia antigen presentation in the CNS of Alzheimer's diseaseR01AG067581 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRADSHAW, ELIZABETH M, ELYAMAN, WASSIM · 2020 to 2024
$3.7MRegulation of inflammatory gene expression during SARS2 infectionR01AI168130 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ivan Marazzi · 2022 to 2026
$3.7MAltered inflammatory response associated with acquired DNMT3A mutationsR01HL153974 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BYUN, MINJI · 2021 to 2025
$3.3MMechanisms of FUS Toxicity in Animal and Cellular Models of ALS/FTD.R01NS106236 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHNEIDER, NEIL ALAN · 2019 to 2022
$2.6MA host-dependent mechanism controlling influenza virus infection by suppressing viral RNA synthesisR01AI143840 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARAZZI, IVAN · 2019 to 2023
$2.1MInterdisciplinary Training in Systems and Developmental Biology and Birth DefectsT32HD075735 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JABS, ETHYLIN WANG · 2013 to 2022
$1.8MAn integrated therapeutic T cell receptor screening platform for adoptive cell therapy in cancerR33CA225539 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI JIANG, NING JENNY · 2018 to 2022
$1.1MNCI NIH HHS R33 CA225539NHLBI NIH HHS R01 HL153974NIAID NIH HHS R01 AI143840NIAID NIH HHS R01 AI168130NIAID NIH HHS T32 AI007647NIAID NIH HHS U01 AI150748NIA NIH HHS R01 AG067581NIA NIH HHS T32 AG000096NICHD NIH HHS T32 HD075735NINDS NIH HHS R01 NS106236NINDS NIH HHS R35 NS122140Wellcome Trust 1017892
Abstract
Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that affects motor neurons and voluntary muscle control
Indexed as
Amyotrophic Lateral SclerosisCD8-Positive T-LymphocytesClone CellsAnimalsDNA HelicasesGene Knock-In TechniquesHumansMiceMotor NeuronsMultifunctional EnzymesMutationRNA HelicasesDNA HelicasesMultifunctional EnzymesRNA HelicasesSETX protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.