ArticleNature2022
The gut metabolite indole-3 propionate promotes nerve regeneration and repair.
Abstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers.
0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
196 citing papers in PubMed.
- Effects of time-restricted feeding and walking exercise on the physical health of female college students with hidden obesity: a randomized trial.Frontiers in public health · 2023Trial
- Engineered probiotic-derived indole-3-propionic acid inhibits ubiquitination via AHR signaling to treat postmenopausal osteoporosis.Gut microbes · 2026Article
- Indole-3-acetic acid production is rare among gut bacteria and reflects OFOR-driven amino acid oxidation in acetogens.Gut microbes · 2026Article
- Skeletal muscle metabolomic markers underlying the enhanced exercise-induced hypertrophy response to resistance training in older adults.GeroScience · 2026Article
- ROS-responsive hydrogel delivering liposomal indole-3-propionic acid promotes spinal cord injury repair by enhancing CX3CL1-CX3CR1 mediated neuron-microglia communication.Materials today. Bio · 2026Article
- An injectable tough hydrogel sealant enabling rapid hemostasis and promoting oral tissue regeneration.Bioactive materials · 2026Article
- Natural Products and Neuroregeneration: Rethinking Discovery Beyond Bioavailability Through Pseudo-Natural Product Design.Biomedicines · 2026Review
- A Microenvironment-Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Aging-Related Changes in the Injury Response of the Peripheral Nervous System.Neuroscience bulletin · 2026Review
- Glycerol-3-Phosphate Attenuates Hypoxic-Ischemic Brain Injury via Modulation of Microglia-Mediated Neuroinflammation.Neurochemical research · 2026Article
- Pre-diagnostic metabolites in peripheral blood of Langerhans cell histiocytosis children with posterior pituitary involvement.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Gut microbiota-derived succinate links proteostasis collapse to α-synuclein pathology and aging.iScience · 2026Article
- Intermittent fasting protects against stress-induced depression and demyelination via the gut microbiota-brain axis.Translational psychiatry · 2026Article
- The role of gut microbiota-mitochondria crosstalk in neurodegeneration: Underlying mechanisms and potential therapies.Neural regeneration research · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.Nature communications · 2026Article
- Bilayer nerve guidance conduits for continuous delivery of NGF@ZIF-8 nanoparticles for peripheral nerve injury repair.Journal of nanobiotechnology · 2026Article
- Buyang Huanwu Decoction promotes neurorepair after spinal cord injury through a Lactobacillus johnsonii-indole-3-lactic acid-AhR-PI3K/Akt axis.Chinese medicine · 2026Article
- Nanoparticle-Mediated Immunometabolic-Epigenetic Remodeling Enhances Schwann Cell-Macrophage Interaction for Sciatic Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
136 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Elisabeth SergerDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
Lucia Luengo-Gutierrez *Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2714-5261
Jessica S Chadwick *Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
Guiping KongDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-7662-6948
Luming ZhouDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7284-1744
Greg CrawfordDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Matt C DanziDr. John T. MacDonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Antonis MyridakisDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-1690-6651
Alexander BrandisTargeted Metabolomics Unit, Weizmann Institute of Science, Rehovot, Israel.
Adesola Temitope BelloUK Dementia Research Institute, Imperial College London, London, UK.
Franziska MüllerDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2070-7508
Alexandros Sanchez-VassopoulosDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-9990-6309
Francesco De VirgiliisDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
Phoebe LiddellDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
Marc Emmanuel DumasNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-9523-7024
Jessica StridDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3690-2201
Sridhar ManiDepartments of Medicine, Molecular Pharmacology and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Dylan DoddDepartment of Pathology, Stanford School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6210-6239
Simone Di GiovanniDivision of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. s.di-giovanni@imperial.ac.uk.ORCID http://orcid.org/0000-0003-3154-5399
Funding
Microbiota-based probiotics to treat inborn errors in metabolismR01AT011396 · NCCIH · STANFORD UNIVERSITY · PI Dylan Dodd · 2022 to 2026
$2.9MMedical Research Council UK MR/M501797/1Medical Research Council UK MR/W022532/1
Abstract
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate
Indexed as
IndolesNerve RegenerationPropionatesWound HealingAnimalsAxonsChemotaxis, LeukocyteClostridiumFastingGanglia, SpinalGastrointestinal MicrobiomeMiceNerve CrushNerve Growth FactorsNeutrophilsRecovery of Functionindole-3 propionateIndolesNerve Growth FactorsPropionates
Identifiers
PMID
35732737What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.