ArticleNature2022
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 106 citations in OpenAlex.
- T cell fate is dictated by different antigen-presenting cells in response to dietary versus gut epithelial self-antigen.Immunity · 2026Article
- ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.Nature immunology · 2026Article
- ID2 orchestrates the final 'E-scape' from the -165-kb Zeb2 enhancer for cDC1 specification.Nature immunology · 2026Article
- Priming of CD8Nature neuroscience · 2026Article
- Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity.Cancer research · 2026Article
- Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8Nature communications · 2026Article
- Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.Science immunology · 2026Article
- Dendritic cell redundancy enables priming of anti-tumor CD4Cancer cell · 2026Article
- CSF1R regulates monocyte subset differentiation and intracellular metabolism.Nature communications · 2026Article
- Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression.Cancer cell · 2026Article
- Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties.Neuron · 2026Article
- The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets.Life science alliance · 2026Article
- mRNA vaccines engage unconventional pathways in CD8Nature · 2026Article
- Intratumoral TScience immunology · 2026Article
- CD8bioRxiv : the preprint server for biology · 2026Article
- Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis.Immunity · 2026Article
- Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells.The Journal of experimental medicine · 2026Article
- Type I interferon restricts mRNA vaccine efficacy through suppression of antigen uptake in cDCs.NPJ vaccines · 2026Article
- Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens.Immunological reviews · 2026Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Tian-Tian LiuDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-9377-9938
Sunkyung KimDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Pritesh DesaiDepartment of Medicine, Washington University in St Louis, School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-4697-9475
Do-Hyun KimDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Xiao HuangDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Stephen T FerrisDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-3340-2607
Renee WuDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Feiya OuDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Takeshi EgawaDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Steven J Van DykenDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-9787-0883
Michael S DiamondDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8791-3165
Peter F JohnsonMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-4145-4725
Masato KuboDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Noda, Japan.ORCID http://orcid.org/0000-0001-7867-3086
Theresa L MurphyDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA. kmurphy@wustl.edu.ORCID http://orcid.org/0000-0002-3505-9630
Washington University in St. Louis · USNational Cancer Institute · USTokyo University of Science · JP
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MNATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MControl of Oncogenic Signaling Through Spatial Organization of Kinases and mRNAsZIABC012098 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JOHNSON, PETER F · 2022 to 2025
$6.0MThe transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6MMolecular Basis of cDC1 DevelopmentR01AI162643 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2025
$2.8MSystemic Neurotropic virus infection effects on GI DysmotilityR01DK122790 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI DIAMOND, MICHAEL S, HANDLEY, SCOTT A. · 2020 to 2023
$2.7MFunction of Wdfy4 in cross-presentation and immunityR01AI150297 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2019 to 2023
$2.5MUnderstanding the Mechanisms of DC Licensing in CD8 T Cell PrimingR01CA248919 · NCI · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2025
$2.3MTargeting chitin in fibrotic lung diseaseR01HL148033 · NHLBI · WASHINGTON UNIVERSITY · PI VAN DYKEN, STEVEN · 2020 to 2023
$1.7MMechanism of c-MYC repression by IRF8 in myeloid lineagesR21AI164142 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2022
$433kTranscriptional basis of embryonic macrophage developmentR21AI163421 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2023
$430kThe role of type 1 dendritic cells in CD4 and CD8 T cell anti-tumor immunityF30CA247262 · NCI · WASHINGTON UNIVERSITY · PI WU, RENEE PAULA · 2021 to 2023
$117kIntramural NIH HHSNCI NIH HHS F30 CA247262NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA248919NHLBI NIH HHS R01 HL148033NIAID NIH HHS R01 AI130152NIAID NIH HHS R01 AI150297NIAID NIH HHS R01 AI162643NIAID NIH HHS R21 AI163421NIAID NIH HHS R21 AI164142NIDDK NIH HHS R01 DK122790NIGMS NIH HHS T32 GM007200NIH HHS 5T32 GM007200
Abstract
The divergence of the common dendritic cell progenitor
Indexed as
Cell DifferentiationDendritic CellsEnhancer Elements, GeneticMutationZinc Finger E-box Binding Homeobox 2AnimalsBasic-Leucine Zipper Transcription FactorsCCAAT-Enhancer-Binding ProteinsEpistasis, GeneticInhibitor of Differentiation Protein 2LymphocytesMiceMyeloid CellsNematospiroides dubiusRepressor ProteinsTh2 CellsBasic-Leucine Zipper Transcription FactorsCCAAT-Enhancer-Binding ProteinsIdb2 protein, mouseInhibitor of Differentiation Protein 2Nfil3 protein, mouseRepressor ProteinsSNFT protein, mouseZEB2 protein, mouseZinc Finger E-box Binding Homeobox 2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.