Evidence map›Paper›PMID 35732733›Full record

ArticleNature2022

De novo design of discrete, stable 3

Prasun Kumar, Neil G Paterson, Jonathan Clayden, Derek N Woolfson

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Role of stereochemistry on electron transport in peptides.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Designability of α-Helical Protein Filaments.Sub-cellular biochemistry · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Secondary structure determines electron transport in peptides.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Prasun KumarSchool of Chemistry, University of Bristol, Bristol, UK. prasun.kumar@bristol.ac.uk.ORCID http://orcid.org/0000-0002-2008-3347
Neil G PatersonDiamond Light Source, Didcot, UK.ORCID http://orcid.org/0000-0003-4292-6971
Jonathan ClaydenSchool of Chemistry, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-5080-9535
Derek N WoolfsonSchool of Chemistry, University of Bristol, Bristol, UK. d.n.woolfson@bristol.ac.uk.ORCID http://orcid.org/0000-0002-0394-3202
University of Bristol · GBDiamond Light Source · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1European Research Council 340764European Research Council WM140008
6 · The paper itself

Abstract

The α-helix is pre-eminent in structural biology

Indexed as

PeptidesProtein Structure, SecondaryCrystallography, X-RayDrug DesignHydrophobic and Hydrophilic InteractionsProtein FoldingProtein StabilityPeptides

Identifiers

PMID35732733
OpenAlexW4283372224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.