Evidence map›Paper›PMID 35732449›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Psoas and Mediastinal Abscesses during Intravenous Tocilizumab Treatment in Multicentric Castleman Disease.

Kazuto Togitani, Fumiya Ogasawara, Yu Arakawa, Natsuki Sugimura, Ryohei Miyazaki, Kensuke Kojima

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kazuto TogitaniDepartment of Hematology, Kochi Medical School, Kochi University, Japan.
Fumiya OgasawaraDepartment of Hematology, Kochi Medical School, Kochi University, Japan.
Yu ArakawaDepartment of Respiratory Medicine and Allergology, Kochi Medical School, Kochi University, Japan.
Natsuki SugimuraDepartment of Orthopedic Surgery, Kochi Medical School, Kochi University, Japan.
Ryohei MiyazakiDepartment of Thoracic Surgery, Kochi Medical School, Kochi University, Japan.
Kensuke KojimaDepartment of Hematology, Kochi Medical School, Kochi University, Japan.
Kōchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tocilizumab has been used to treat idiopathic multicentric Castleman disease (iMCD). As tocilizumab prevents interleukin-6 from exerting pro-inflammatory effects, there is some concern about a delayed diagnosis of severe infections during tocilizumab treatment. Although serious infections during tocilizumab therapy have been previously described in patients with rheumatoid arthritis, they have not been reported in iMCD. We herein report a case of disseminated Staphylococcus aureus infection after a superficial skin wound followed by psoas and mediastinal abscesses with pyogenic spondylodiscitis in an iMCD patient with diabetes. Physicians should be alert for the occurrence of disseminated S. aureus infection after even minor skin injury during tocilizumab therapy.

Indexed as

Castleman DiseaseAbscessAntibodies, Monoclonal, HumanizedHumansStaphylococcus aureusAntibodies, Monoclonal, Humanizedtocilizumababscessmediastinummethicillin-susceptible Staphylococcus aureusmulticentric Castleman diseasepsoastocilizumab

Identifiers

PMID35732449
PMCPMC9970794
OpenAlexW4283367747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.