Evidence map›Paper›PMID 35732344›Full record

ArticleLupus science & medicine2022

Phenotypical changes and clinical significance of CD4

Shiwen Yuan, Yanting Zeng, Jiawei Li, Cuicui Wang, Weinian Li, Zhixiang He, Jinghua Ye, Fangfei Li, Yi Chen, Xiaojun Lin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University
    Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  8. Combined assessment of 25(OH)D, CD4Frontiers in immunology · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shiwen Yuan *Department of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.ORCID 0000-0002-0919-6252
Yanting Zeng *Department of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Jiawei Li *The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China.
Cuicui WangDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Weinian LiDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Zhixiang HeDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Jinghua YeDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Fangfei LiDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Yi ChenDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Xiaojun LinDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Na YuGuangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiaoyan CaiDepartment of Rheumatology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China caixytracy@126.com.
Guangzhou First People's Hospital · CNGuangzhou Eighth People's Hospital · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveT cells display significant phenotypical changes and play multiple roles in promoting the immune response in SLE. The frequencies of T cell subpopulations in SLE are still not well understood. To better understanding the phenotypic abnormalities of T cells in SLE will help us to clarify disease immunopathology and to find promising biomarkers for disease monitoring and control.

methodsPeripheral blood CD4

resultsThere was a broad range of anomalies in the proportion of T cell subsets in patients with SLE compared with that of the HCs. Compared with the HCs, a higher frequency of memory T cells and a lower frequency of naïve T cells were noted in patients with SLE. In addition, an imbalance of CD28

conclusionThe proportions of CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesLupus Erythematosus, SystemicCD28 AntigensHumansT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsCD28 Antigenslupus erythematosus, systemiclupus nephritisT-lymphocytes, helper-inducer

Identifiers

PMID35732344
PMCPMC9226979
OpenAlexW4283273516

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.