ArticleDiving and hyperbaric medicine2022
Blood pressure in rats selectively bred for their resistance to decompression sickness.
Article in Diving and hyperbaric medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Gene expression of Decompression Sickness-resistant rats through a miRnome/transcriptome crossed approach.Communications biology · 2024Article
- Decompression illness: a comprehensive overview.Diving and hyperbaric medicine · 2024Article
- Effect of angiotensin II on irradiation exacerbated decompression sickness.Scientific reports · 2023Article
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3 authors at 1 institution in 1 country.
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Abstract
introductionSusceptibility to decompression sickness (DCS) is characterised by a wide inter-individual variability whose origins are still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with a 3-fold greater resistance to DCS than standard rats. Based on its previously reported relation with decompression outcomes, we assessed whether modification in vascular function is associated with resistance to DCS.
methodsThe arterial pressure response to intravenous administration of acetylcholine (ACh, 5 μg.kg
resultsThere was a non-significant tendency for a lower diastolic (DBP) and mean blood pressure (MBP) in DCS-resistant rats. After ACh administration, MBP was significantly lower in resistant rats, for both males (P = 0.007) and females (P = 0.034). After administration of adrenaline 10 μg.kg
conclusionsResistance to DCS in rats is associated to a trend towards a lower vascular tone but not blood pressure reactivity. Whether these differences are a component of the susceptibility to DCS remains to be confirmed.
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