ArticleNature2022
Integrated multi-omic characterization of congenital heart disease.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Single-cell reconstruction and mutation enrichment analysis identifies dysregulated cardiomyocyte and endothelial cells in congenital heart disease.Physiological genomics · 2023Pooled it
- The enduring value of single-center studies in the era of big data: A message to early career pediatric cardiologist.International journal of cardiology. Congenital heart disease · 2026Article
- Targeted Quantitative Metabolomics and Lipidomics Reveal Dysregulated Metabolic Networks and a Serum Candidate Biomarker for Atrial Fibrillation.Metabolites · 2026Article
- [Research progress on the regulatory role and mechanisms of the Hippo signaling pathway in the pathogenesis of congenital heart disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Voxel-scale diffusion tensor phenomapping of the healthy and pressure-overloaded human heart.Nature biomedical engineering · 2026Article
- Mitochondrial protein OPA3 sustains cardiac function by regulating calcium handling in male mice.Nature communications · 2026Article
- Primary cilia promote cardiac fibrosis and limit heart function after myocardial infarction.bioRxiv : the preprint server for biology · 2026Article
- Integrative analysis of bulk and single-nucleus transcriptomes suggests proteostasis- and metabolism-related alterations in the right ventricular outflow tract of non-syndromic Tetralogy of Fallot.Functional & integrative genomics · 2026Article
- Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease.Pediatric discovery · 2026Article
- ELABELA Targets Mitochondria to Modulate Heart Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genetic drivers of congenital cardiac fibrosis.Communications biology · 2026Review
- Cardiac fibroblasts in myocardial injury and heart failure.European heart journal · 2026Review
- Maternal Cardiac Disease and Congenital Heart Disease Risk in Offspring.JAMA network open · 2026Article
- Single-cell omics uncovers novel pathological mechanisms and therapeutic targets for congenital heart diseases: insights from integrated intercellular communication analysis.Stem cell research & therapy · 2026Review
- An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.Genome biology · 2026Article
- Ventricular assist device unloading reverses microvascular senescence in single ventricle disease.Nature cardiovascular research · 2026Article
- Single cell transcriptomic landscape of adult and pediatric non-ischemic cardiomyopathy.Journal of molecular and cellular cardiology · 2026Review
- Multi-omic analysis of human PHACTR1 signaling networks.Communications biology · 2026Article
- Leveraging Single-Cell Technologies to Advance Understanding of Myocardial Disease.Circulation research · 2026Review
- Big data analytics for CLEC5A dynamics based on single cell genomics and proteomics reveal its diverse functions in human diseases.Nanotheranostics · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Matthew C Hill *Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
Zachary A Kadow *Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1254-377X
Hali LongInterdepartmental Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.
Yuka MorikawaTexas Heart Institute, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4571-8409
Thomas J MartinDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Emma J BirksDepartment of Physiology, University of Kentucky, Lexington, KY, USA.
Kenneth S CampbellDepartment of Physiology, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-5615-5958
Jeanne NerbonneCenter for Cardiovascular Research, Departmental of Medicine, Cardiovascular Division, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-8334-8499
Kory LavineCenter for Cardiovascular Research, Departmental of Medicine, Cardiovascular Division, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-1948-9945
Lalita WadhwaSection of Cardiothoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Jun WangDepartment of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6874-9331
Diwakar TuragaSection of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Iki AdachiSection of Cardiothoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
James F MartinProgram in Developmental Biology, Baylor College of Medicine, Houston, TX, USA. jfmartin@bcm.edu.ORCID http://orcid.org/0000-0002-7842-9857
Baylor College of Medicine · USUniversity of Kentucky · USWashington University in St. Louis · USBroad Institute · USThe University of Texas Health Science Center at Houston · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MPitx2 in atrial fibrillationR01HL118761 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2014 to 2025
$6.1MHippo and Wnt Signaling in Cardiac RegenerationR01HL127717 · NHLBI · TEXAS HEART INSTITUTE · PI MARTIN, JAMES F · 2016 to 2023
$4.4MSpecification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MDual filament control of myocardial power and hemodynamicsR01HL148785 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kenneth S Campbell, Thomas Kampourakis · 2020 to 2026
$3.2MGenetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0MOptical elastography for assessment of myocardial regenerationR01HL130804 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARIN, KIRILL V, MARTIN, JAMES F · 2016 to 2019
$2.9MLength-dependent activation in human myocardiumR01HL149164 · NHLBI · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S, TANNER, BERTRAND C.W. · 2020 to 2023
$2.8MMolecular Regulatory Mechanism of Cranial Neural Crest DevelopmentR01DE029014 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WANG, JUN · 2020 to 2024
$1.8MSingle Cell Spatial Analysis in TissueR50CA243707 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BURKS, JARED KYLE · 2020 to 2024
$1.3MNCI NIH HHS P30 CA016672NCI NIH HHS P30 CA125123NCI NIH HHS R50 CA243707NCRR NIH HHS S10 RR024574NHLBI NIH HHS F30 HL145908NHLBI NIH HHS F31 HL156681NHLBI NIH HHS R01 HL118761NHLBI NIH HHS R01 HL127717NHLBI NIH HHS R01 HL130804NHLBI NIH HHS R01 HL142704NHLBI NIH HHS R01 HL148785NHLBI NIH HHS R01 HL149164NHLBI NIH HHS R35 HL161185NHLBI NIH HHS R56 HL142704NHLBI NIH HHS T32 HL007208NIDCR NIH HHS K01 DE026561NIDCR NIH HHS R01 DE029014NIH HHS S10 OD023469
Abstract
The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of patients with CHD survive into adulthood, but many suffer premature death from heart failure and non-cardiac causes
Indexed as
Heart Defects, CongenitalPhenotypeBone Morphogenetic Protein ReceptorsCardiomyopathy, DilatedCardiomyopathy, HypertrophicDisease ProgressionFibroblastsForkhead Transcription FactorsHumansHypoplastic Left Heart SyndromeImage CytometryInsulin ResistanceMonocytesMyocytes, CardiacRNA-SeqSignal TransductionBone Morphogenetic Protein ReceptorsCRIM1 protein, humanForkhead Transcription FactorsYAP-Signaling Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.