Evidence map›Paper›PMID 35732145›Full record

ArticleCell reports. Medicine2022

Filamentous bacteriophage delays healing of Pseudomonas-infected wounds.

Michelle S Bach, Christiaan R de Vries, Arya Khosravi, Johanna M Sweere, Medeea C Popescu, Qingquan Chen, Sally Demirdjian, Aviv Hargil, Jonas D Van Belleghem, Gernot Kaber and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Prophages in Skin Pathogens: From Virulence to Therapy.Pathogens (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Trans-Kingdom dsRNA Sensing:bioRxiv : the preprint server for biology · 2026
    Article
  7. Phage-Mediated Iron Acquisition bybioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Co-infection withISME communications · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 7 institutions in 1 country.

Michelle S BachDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
Christiaan R de VriesDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Arya KhosraviDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Johanna M SweereDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
Medeea C PopescuDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
Qingquan ChenDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Sally DemirdjianDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Aviv HargilDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Jonas D Van BelleghemDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Gernot KaberDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Maryam HajfathalianDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth B BurgenerCenter for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Dan LiuDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Quynh-Lam TranDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Tejas DharmarajDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
Maria BirukovaDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
Vivekananda SunkariDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Stanford Immunology, Stanford University, Stanford, CA 94305, USA.
Swathi BalajiDivision of Pediatric Surgery, Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Nandini GhoshDepartment of Surgery, Indiana University, Indianapolis, IN 46202, USA.
Shomita S Mathew-SteinerDepartment of Surgery, Indiana University, Indianapolis, IN 46202, USA.
Mohamed S El MasryDepartment of Surgery, Indiana University, Indianapolis, IN 46202, USA.
Sundeep G KeswaniDivision of Pediatric Surgery, Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Niaz BanaeiDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA; Division of Pathology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Laurence NedelecDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Chandan K SenDepartment of Surgery, Indiana University, Indianapolis, IN 46202, USA.
Venita ChandraDepartment of Surgery, Division of Vascular Surgery, Stanford University, Stanford, CA 94305, USA.
Patrick R SecorDivision of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
Gina A SuhDivision of Infectious Diseases, Mayo Clinic, Rochester, MN 55902, USA.
Paul L BollykyDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: pbollyky@stanford.edu.
Stanford University · USStanford Medicine · USIndiana University – Purdue University Indianapolis · USBaylor College of Medicine · USMayo Clinic in Florida · USUniversity of Montana · USUniversity of Pennsylvania · US

Funding

EMERGING INFECTIOUS DISEASEST32AI007502 · NIAID · STANFORD UNIVERSITY · PI Prasanna Jagannathan, DAVID A. RELMAN · 1995 to 2026
$6.8M
Stanford Training Program in Lung BiologyT32HL129970 · NHLBI · STANFORD UNIVERSITY · PI CORNFIELD, DAVID N., NICOLLS, MARK ROBERT · 2016 to 2025
$3.2M
Stanford ChEM-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM139791 · NIGMS · STANFORD UNIVERSITY · PI Carolyn Bertozzi, Christine Jacobs-Wagner · 2021 to 2026
$2.4M
Pathogenesis of Pf Bacteriophages in Pseudomonas Cystic Fibrosis lung InfectionsR01HL148184 · NHLBI · STANFORD UNIVERSITY · PI MILLA, CARLOS · 2019 to 2022
$1.7M
Studies on bacteriophages in respiratory diseasesK24AI166718 · NIAID · STANFORD UNIVERSITY · PI Paul L Bollyky · 2022 to 2026
$815k
Heparanase and Regulatory T cell Stability and FunctionR21AI133240 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2019
$438k
Biofilms and Bacteriophages in Chronic Wound InfectionsR21AI133370 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2017 to 2017
$319k
Anti-biofilm laser-mediated photothermal ablation via complex noble metal nanostructuresK99EB028838 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI HAJFATHALIAN, MARYAM · 2020 to 2022
$248k
Immunization against Pf bacteriophage in Pseudomonas aeruginosa infectionK08AI151089 · NIAID · STANFORD UNIVERSITY · PI DE VRIES, CHRISTIAAN ROBERT · 2021 to 2021
$162k
NHLBI NIH HHS R01 HL148184NHLBI NIH HHS T32 HL129970NIAID NIH HHS K08 AI151089NIAID NIH HHS K24 AI166718NIAID NIH HHS R21 AI133240NIAID NIH HHS R21 AI133370NIAID NIH HHS T32 AI007502NIBIB NIH HHS K99 EB028838NIGMS NIH HHS T32 GM139791
6 · The paper itself

Abstract

Chronic wounds infected by Pseudomonas aeruginosa (Pa) are characterized by disease progression and increased mortality. We reveal Pf, a bacteriophage produced by Pa that delays healing of chronically infected wounds in human subjects and animal models of disease. Interestingly, impairment of wound closure by Pf is independent of its effects on Pa pathogenesis. Rather, Pf impedes keratinocyte migration, which is essential for wound healing, through direct inhibition of CXCL1 signaling. In support of these findings, a prospective cohort study of 36 human patients with chronic Pa wound infections reveals that wounds infected with Pf-positive strains of Pa are more likely to progress in size compared with wounds infected with Pf-negative strains. Together, these data implicate Pf phage in the delayed wound healing associated with Pa infection through direct manipulation of mammalian cells. These findings suggest Pf may have potential as a biomarker and therapeutic target in chronic wounds.

Indexed as

InovirusPseudomonas InfectionsWound InfectionAnimalsBiofilmsHumansMammalsProspective StudiesPseudomonasPseudomonas aeruginosaWound Healingbacteriophagefilamentous phageimmunologymicrobiologyPfPseudomonaswounds

Identifiers

PMID35732145
PMCPMC9244996
OpenAlexW4283264380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.