ArticleBritish journal of pharmacology2022
β
Open access · greenAbstract read
In one paragraph
Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Agonist-specific conformational dynamics at the βBritish journal of pharmacology · 2026Article
- Biased signaling of β2-adrenergic receptor in physiological and pathological states.Cellular & molecular biology letters · 2026Review
- Dynamic Pathway Selectivity of TAS2R5 toward or Away from β-Arrestin or G Protein from Biased Agonists.Biochemistry · 2026Article
- Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production.Respiratory research · 2026Article
- Biased Agonism at β-Adrenoceptor Subtypes: A Drug Development Perspective.Handbook of experimental pharmacology · 2026Review
- Class A and B GPCRs trigger rapid GαCommunications biology · 2025Article
- Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases.American journal of respiratory cell and molecular biology · 2025Review
- GPCR-A17 MAAP: mapping modulators, agonists, and antagonists to predict the next bioactive target.Journal of cheminformatics · 2025Article
- Integrative Roles of Pro-Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma.Immunological reviews · 2025Review
- Adrenoceptor Desensitization: Current Understanding of Mechanisms.Pharmacological reviews · 2024Review
- Identification of a β-arrestin-biased negative allosteric modulator for the βProceedings of the National Academy of Sciences of the United States of America · 2023Article
- In silico identification of a βProceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Francesco De PascaliDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Michael IppolitoDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Emily WolfeRutgers Institute for Translational Medicine and Science, New Brunswick, New Jersey and Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey, Piscataway, New Jersey, USA.
Konstantin E KomolovDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Nathan HopfingerDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Douglas LemenzeRutgers Institute for Translational Medicine and Science, New Brunswick, New Jersey and Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey, Piscataway, New Jersey, USA.
Nicholas KimRutgers Institute for Translational Medicine and Science, New Brunswick, New Jersey and Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey, Piscataway, New Jersey, USA.
Roger S ArmenDepartment of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Steven S AnRutgers Institute for Translational Medicine and Science, New Brunswick, New Jersey and Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey, Piscataway, New Jersey, USA.
Charles P ScottDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Thomas Jefferson University · USRutgers, The State University of New Jersey · US
Funding
X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8MNew Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9MProject 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENOVIC, JEFFREY L · 2013 to 2023
$23.9MG Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3MNovel Biased Beta2-AR Ligands as Asthma TherapeuticsR01AI161296 · NIAID · DUKE UNIVERSITY · PI CHU, HONG W, DICKEY, BURTON F · 2021 to 2025
$3.2MRegulation of G protein-coupled receptor signaling and traffickingR35GM122541 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2017 to 2021
$2.5MCharacterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular functionR01HL136219 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L, TILLEY, DOUGLAS · 2017 to 2020
$2.5MStructural and dynamic analysis of GRK interaction with G protein-coupled receptorsR01HL142310 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2018 to 2021
$2.1MTraining Program in Cellular, Biochemical, and Molecular SciencesT32GM100836 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2012 to 2016
$809kCharacterization and Development of Gs-biased ligands of Beta2-Adrenergic ReceptorF31HL139104 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI IPPOLITO, MICHAEL · 2018 to 2019
$90kNCATS NIH HHS UL1 TR003017NCI NIH HHS P30 CA056036NHLBI NIH HHS F31 HL139104NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL058506NHLBI NIH HHS R01 HL136219NHLBI NIH HHS R01 HL142310NIAID NIH HHS R01 AI161296NIGMS NIH HHS R35 GM122541NIGMS NIH HHS T32 GM100836
Abstract
background and purposeβ-Adrenoceptor agonists relieve airflow obstruction by activating β EXPERIMENTAL APPROACH: G KEY
resultsWe identified ractopamine, dobutamine, and higenamine as G CONCLUSION AND IMPLICATIONS: Our work demonstrates that G
Indexed as
AsthmaReceptors, Adrenergic, beta-2Adrenergic beta-Agonistsbeta-Arrestin 1beta-ArrestinsGTP-Binding Protein alpha Subunits, GsHumansPhenotypeSignal TransductionAdrenergic beta-Agonistsbeta-Arrestin 1beta-ArrestinsGTP-Binding Protein alpha Subunits, GsReceptors, Adrenergic, beta-2airway smooth muscleasthmabiased signallingdesensitizationG proteinG protein-coupled receptorβ2-adrenoceptorβ-arrestins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.