Evidence map›Paper›PMID 35731989›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2022

Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia Treated With Blood or Marrow Transplantation: The Results of the BMT Survivor Study.

Saro H Armenian, Yanjun Chen, Lindsay Hageman, Jessica Wu, Wendy Landier, Alysia Bosworth, Liton Francisco, Elizabeth Schlichting, Ravi Bhatia, Donna Salzman and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Preventive health care in blood cancer survivors: results from the ABC study.Journal of cancer research and clinical oncology · 2023
    Article
  6. Article
  7. Article
  8. Managing Survivorship after Hematopoietic Cell Transplantation.Current hematologic malignancy reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Saro H ArmenianDepartment of Population Sciences, City of Hope, Duarte, CA.ORCID 0000-0003-2604-8603
Yanjun ChenInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Lindsay HagemanInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Jessica WuInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Wendy LandierInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-3319-5652
Alysia BosworthDepartment of Population Sciences, City of Hope, Duarte, CA.ORCID 0000-0002-0662-5699
Liton FranciscoInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-8138-9932
Elizabeth SchlichtingInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Ravi BhatiaDivision of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL.
Donna SalzmanDivision of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL.
F Lennie WongDepartment of Population Sciences, City of Hope, Duarte, CA.ORCID 0000-0002-4333-5017
Daniel J WeisdorfDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-8078-8579
Stephen J FormanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.ORCID 0000-0002-2803-4152
Mukta AroraDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-9362-0556
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-7755-5683
University of Alabama at Birmingham · USCity of Hope · USUniversity of Minnesota · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
BMT Survivor Study-2 (BMTSS-2)U01CA213140 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATIA, SMITA · 2019 to 2023
$6.8M
BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDYR01CA078938 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI BHATIA, SMITA · 2000 to 2003
$1.6M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA078938NCI NIH HHS U01 CA213140
6 · The paper itself

Abstract

purposeBlood or marrow transplantation (BMT) is an integral part of consolidation and/or salvage therapy for patients with acute myeloid leukemia (AML). With the growing population of AML survivors, there is a need to understand the quality of their survival. MATERIALS AND

methodsThis multisite study included 1,369 2-year survivors who underwent BMT for AML between 1974 and 2014 at age ≥ 21 years and 1,310 siblings. Using Common Terminology Criteria for Adverse Events, severe/life-threatening and fatal chronic health conditions were identified. Multivariable regression analysis was used to compare the risk of severe/life-threatening conditions and health status between survivors and siblings, and to identify risk factors for health conditions among BMT survivors.

resultsThe prevalence of severe/life-threatening conditions was 54.9% in BMT survivors compared with 28.5% in siblings (

conclusionThe burden of severe/life-threatening conditions is substantially higher in BMT recipients when compared with an unaffected comparison group, contributing to an increasing incidence of non-RRM over time. Chronic graft-versus-host disease was an important risk factor for severe/life-threatening/fatal conditions among BMT recipients, informing the need for close monitoring to anticipate and manage morbidity.

Indexed as

Graft vs Host DiseaseLeukemia, Myeloid, AcuteVenous ThromboembolismAdultBone MarrowBone Marrow TransplantationChronic DiseaseHumansMorbiditySurvivorsYoung Adult

Identifiers

PMID35731989
PMCPMC9553373
OpenAlexW4283269937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.