ArticleScience advances2022
Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Common alterations of whole and subregion-specific amygdala intrinsic functional connectivity across psychiatric disorders: a meta-analysis.Molecular psychiatry · 2026Pooled it
- Effects of transcranial magnetic stimulation on spatial memory: a systematic review across animal and human studies.Frontiers in behavioral neuroscience · 2026Pooled it
- Comparative efficacy of different modalities of transcranial magnetic stimulation for treating Parkinson's disease with depression: a systematic review and network meta-analysis.Frontiers in neurology · 2025Pooled it
- OFC-induced network modularity improves positive symptoms and attentional alertness in schizophrenia: a combined rTMS-fMRI study.Nature communications · 2026Trial
- Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial.The American journal of psychiatry · 2026Trial
- Causal connectivity maps derived from single-pulse interleaved TMS/fMRI.Scientific reports · 2026Trial
- Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trial.Molecular psychiatry · 2025Trial
- Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes.Addiction biology · 2024Trial
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study.Brain stimulationTrial
- Low-Intensity Focused Ultrasound of the Amygdala in Depression and Anxiety: A First-in-Human Active-Controlled Trial.medRxiv : the preprint server for health sciences · 2026Article
- How indirect is too indirect? Structural pathways to the sgACC and the antidepressant response to TMS.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- Aberrant cortico-striato-limbic functional connectivity to alcohol cues in co-occurring bipolar disorder and alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Ventrolateral prefrontal-amygdala repetitive transcranial magnetic stimulation (rTMS) modulation of impulsivity in borderline personality disorder: a proof-of-concept study.Scientific reports · 2026Article
- Efficacy and safety of repetitive transcranial magnetic stimulation in anorexia and bulimia nervosa: a systematic review and meta-analysis.Annals of general psychiatry · 2026Review
- rTMS Suppresses Tobacco Craving via Enhanced Prefronto-Striato-Thalamic Connectivity.Addiction biology · 2026Article
- Habitual Aerobic Exercise Is Associated with Reduced Negative Emotional Elicitation: An fNIRS Study.Brain sciences · 2026Article
- The Rostral Ventrolateral Medulla Input to Central Amygdala Regulates Anxiety-Like Behaviors in Mice for Chronic Light Exposure.CNS neuroscience & therapeutics · 2026Article
- Continuous Theta Burst to Supplementary Motor Area Modulates Groove.Annals of the New York Academy of Sciences · 2026Article
- Target variability and stability of neuroimaging-guided transcranial magnetic stimulation of the amygdala circuitry for posttraumatic stress disorder.Research square · 2026Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
The amygdala processes valenced stimuli, influences emotion, and exhibits aberrant activity across anxiety disorders, depression, and PTSD. Interventions modulating amygdala activity hold promise as transdiagnostic psychiatric treatments. In 45 healthy participants, we investigated whether transcranial magnetic stimulation (TMS) elicits indirect changes in amygdala activity when applied to ventrolateral prefrontal cortex (vlPFC), a region important for emotion regulation. Harnessing in-scanner interleaved TMS/functional MRI (fMRI), we reveal that vlPFC neurostimulation evoked acute and focal modulations of amygdala fMRI BOLD signal. Larger TMS-evoked changes in the amygdala were associated with higher fiber density in a vlPFC-amygdala white matter pathway when stimulating vlPFC but not an anatomical control, suggesting this pathway facilitated stimulation-induced communication between cortex and subcortex. This work provides evidence of amygdala engagement by TMS, highlighting stimulation of vlPFC-amygdala circuits as a candidate treatment for transdiagnostic psychopathology. More broadly, it indicates that targeting cortical-subcortical structural connections may enhance the impact of TMS on subcortical neural activity and, by extension, subcortex-subserved behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.