ArticlePloS one2022
Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- Beyond the Apnea-Hypopnea Index: Circulating Biomarkers and Device-Based Metrics for Cardiometabolic Risk Stratification in Obstructive Sleep Apnea.Journal of clinical medicine · 2026Review
- Gender differences in the psychosocial and functional impact of obstructive sleep apnea: findings from the SHINE patient survey.Sleep & breathing = Schlaf & Atmung · 2026Article
- Endocrinology and the Lung: Exploring the Bidirectional Axis and Future Directions.Journal of clinical medicine · 2025Article
- Steroid hormone biosynthesis and dietary related metabolites associated with excessive daytime sleepiness.EBioMedicine · 2025Article
- Walking the fine line between OSA and aging.Sleep & breathing = Schlaf & Atmung · 2025Review
- Cardiovascular Disease Risk in Women with Menopause.Journal of clinical medicine · 2025Review
- Sex-specific associations between sleep apnoea and lung cancer risk in patients with COPD: a nationwide prospective cohort study.The Lancet regional health. Europe · 2025Article
- A possible important regulatory role of estrogen in obstructive sleep apnea hypoventilation syndrome.Frontiers in medicine · 2025Review
- Prevalence and determinants of high-risk obstructive sleep apnea among hypertensive patients in referral hospitals of the Amhara Region, Northwest Ethiopia, 2022.Frontiers in sleep · 2025Article
- Research progress on the clinical subtyping of obstructive sleep apnea hypopnea syndrome.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Chronic intermittent hypoxia-induced hypertension: the impact of sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Review
- Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options.Translational stroke research · 2024Review
- Waking Up to the Issue! Research Inattention and Sex-Related Differences Warrant More Sleep Studies in Female Athletes.Sports medicine (Auckland, N.Z.) · 2024Review
- Sleep Pattern, Lifestyle Pattern, and Risks of Overall and 20 Types of Cancers: Findings From the UK Biobank Cohort.International journal of public health · 2024Article
- On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: which came first, the chicken or the egg?The Journal of physiology · 2023Article
- A Prospective Study on Obstructive Sleep Apnea, Clinical Profile and Polysomnographic Variables.Journal of personalized medicine · 2023Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study.
objectiveTo investigate whether serum concentration of estrogens and progesterone are associated with the prevalence of sleep apnea symptoms in middle-aged women of the general population.
methodsWe analyzed data from 774 women (40-67 years) from 15 study centers in seven countries participating in the second follow-up of the European Community Respiratory Health Survey (2010-2012). Multiple logistic regression models were fitted with self-reported symptoms of sleep apnea as outcomes and serum concentrations of various estrogens and progesterone as predictors. All analyses were adjusted for relevant covariates including age, BMI, education, study center, smoking habits, and reproductive age.
resultsAmong all included women, a doubling of serum concentrations of estrone and progesterone was associated with 19% respectively 9% decreased odds of snoring. Among snorers, a doubling of the concentrations of 17β-estradiol, estrone and estrone 3-sulfate was associated with 18%, 23% and 17% decreased odds of breathing irregularly, and a doubling of the progesterone concentration was further associated with 12% decreased odds of waking up suddenly with a chocking sensation. Other evaluated associations were not statistically significant.
conclusionsMiddle-aged women with low serum estrogen and progesterone levels are more likely to snore and report symptoms of obstructive sleep apnea.
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