Evidence map›Paper›PMID 35731701›Full record

ArticleACS infectious diseases2022

Structural and Mechanistic Insights into

Wuan-Geok Saw, Chen Yen Leow, Amaravadhi Harikishore, Joon Shin, Malcolm S Cole, Wassihun Wedajo Aragaw, Priya Ragunathan, Pooja Hegde, Courtney C Aldrich, Thomas Dick and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. TargetingACS omega · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Wuan-Geok SawSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.ORCID 0000-0002-2510-387X
Chen Yen LeowSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Amaravadhi HarikishoreSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.ORCID 0000-0001-6552-1534
Joon ShinSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.ORCID 0000-0002-8669-7034
Malcolm S ColeUniversity of Minnesota, College of Pharmacy, Department of Medicinal Chemistry 8-101 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States.
Wassihun Wedajo AragawCenter for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, New Jersey 07110, United States.
Priya RagunathanSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.ORCID 0000-0002-2039-4890
Pooja HegdeUniversity of Minnesota, College of Pharmacy, Department of Medicinal Chemistry 8-101 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States.
Courtney C AldrichUniversity of Minnesota, College of Pharmacy, Department of Medicinal Chemistry 8-101 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-9261-594X
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, New Jersey 07110, United States.
Gerhard GrüberSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.ORCID 0000-0002-5730-8319
Nanyang Technological University · SGUniversity of Minnesota · USGeorgetown University · USHackensack Meridian Health · US

Funding

Target based discovery of next generation pyrazinamideR01AI106398 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DICK, THOMAS · 2013 to 2022
$7.1M
Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
NIAID NIH HHS R01 AI106398NIAID NIH HHS R01 AI132374
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mycobacterium abscessusPyrazinamideAntitubercular AgentsCarboxy-LyasesAntitubercular Agentsaspartate 4-decarboxylaseCarboxy-LyasesPyrazinamidepyrazinoic acidaspartate decarboxylasecoenzyme AMycobacterium abscessusnontuberculous mycobacteriapyrazinamidepyrazinoic acid

Identifiers

PMID35731701
PMCPMC10517418
OpenAlexW4283321420

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.