ArticleeLife2022
Different brain systems support learning from received and avoided pain during human pain-avoidance learning.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans.Pain · 2026Article
- Mechanisms Underlying Pain Avoidance in Complex Regional Pain Syndrome.European journal of pain (London, England) · 2026Observational
- Review
- Article
- Investigating the Influence of Experimentally Induced Secondary Hyperalgesia on Pain Prediction Error Encoding in Healthy Individuals: A Novel Virtual Reality Protocol.European journal of pain (London, England) · 2025Article
- Expectation generation and its effect on subsequent pain and visual perception.PLoS computational biology · 2025Article
- Intersect between brain mechanisms of conditioned threat, active avoidance, and reward.Communications psychology · 2025Review
- Article
- Exploring Brain Size Asymmetry and Its Relationship with Predation Risk Among Chinese Anurans.Biology · 2025Article
- Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers.NeuroImage. Clinical · 2025Article
- The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking.eNeuro · 2024Article
- How Instructions, Learning, and Expectations Shape Pain and Neurobiological Responses.Annual review of neuroscience · 2023Review
- Pharmacological Support for the Treatment of Obesity-Present and Future.Healthcare (Basel, Switzerland) · 2023Review
- Review
- Computational perspectives on human fear and anxiety.Neuroscience and biobehavioral reviews · 2023Review
- Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex.Frontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both unexpected pain and unexpected pain absence can drive avoidance learning, but whether they do so via shared or separate neural and neurochemical systems is largely unknown. To address this issue, we combined an instrumental pain-avoidance learning task with computational modeling, functional magnetic resonance imaging (fMRI), and pharmacological manipulations of the dopaminergic (100 mg levodopa) and opioidergic (50 mg naltrexone) systems (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.