Evidence map›Paper›PMID 35731626›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes.

Elise Hickman, Alexis Payton, Parker Duffney, Heather Wells, Agathe S Ceppe, Stephanie Brocke, Aleah Bailey, Meghan E Rebuli, Carole Robinette, Brian Ring and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Review
  10. Review
  11. Article
  12. E-Cigarette Use, Cigarette Smoking, and Sex Are Associated With Nasal Microbiome Dysbiosis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Airway Proteotypes of E-Cigarette Users Overlap with Those Found in Asthmatics.American journal of respiratory cell and molecular biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems.International journal of environmental research and public health · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Elise HickmanCenter for Environmental Medicine, Asthma, and Lung Biology.ORCID 0000-0001-6152-050X
Alexis PaytonCenter for Environmental Medicine, Asthma, and Lung Biology.
Parker DuffneyCenter for Environmental Medicine, Asthma, and Lung Biology.
Heather WellsCenter for Environmental Medicine, Asthma, and Lung Biology.
Agathe S CeppeMarsico Lung Institute, School of Medicine.
Stephanie BrockeCenter for Environmental Medicine, Asthma, and Lung Biology.
Aleah BaileyCenter for Environmental Medicine, Asthma, and Lung Biology.
Meghan E RebuliCenter for Environmental Medicine, Asthma, and Lung Biology.ORCID 0000-0003-1918-2257
Carole RobinetteCenter for Environmental Medicine, Asthma, and Lung Biology.
Brian RingCenter for Environmental Medicine, Asthma, and Lung Biology.
Julia E RagerCenter for Environmental Medicine, Asthma, and Lung Biology.ORCID 0000-0002-2882-5042
Neil E AlexisCenter for Environmental Medicine, Asthma, and Lung Biology.
Ilona JaspersCenter for Environmental Medicine, Asthma, and Lung Biology.ORCID 0000-0001-8728-0305
Center for Environmental Health · USUniversity of North Carolina at Chapel Hill · USLung Institute · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
The UNC Chapel Hill Superfund Research Program (UNC-SRP)P42ES031007 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Gray · 2020 to 2026
$22.2M
The Impact of Tobacco Exposure on the Lungs Innate Defense SystemP50HL120100 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRAN, ROBERT · 2013 to 2017
$21.0M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
UNC PREP in the Biomedical Sciences - Administrative SupplementR25GM089569 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBINSON, DONITA L, RODRIGUEZ-ROMAGUERA, JOSE · 2010 to 2024
$5.6M
E-cig flavors and their effects on respiratory innate immune responsesR01HL139369 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA · 2017 to 2020
$2.4M
Effects of Pod E-Cigarettes on Respiratory Mucosal Immune DefensesF31HL154758 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HICKMAN, ELISE DANIELLE · 2020 to 2021
$63k
NHLBI NIH HHS F31 HL154758NHLBI NIH HHS P50 HL120100NHLBI NIH HHS R01 HL139369NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES031007NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsVapingBiomarkersHomeostasisHumansMatrix Metalloproteinase 2Vascular Endothelial Growth Factor ABiomarkersMatrix Metalloproteinase 2Vascular Endothelial Growth Factor Aimmune suppressionmachine learningpod e-cigarettes

Identifiers

PMID35731626
PMCPMC9746848
OpenAlexW4283275588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.