Evidence map›Paper›PMID 35731459›Full record

ArticleObesity surgery2022

Colorectal Cancer Risk Is Impacted by Sex and Type of Surgery After Bariatric Surgery.

Hisham Hussan, Samuel Akinyeye, Maria Mihaylova, Eric McLaughlin, ChienWei Chiang, Steven K Clinton, David Lieberman

Abstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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  17. The implication of gut microbiota in recovery from gastrointestinal surgery.Frontiers in cellular and infection microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hisham HussanDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The Ohio State University, 395 W. 12th Avenue, 2nd floor, Columbus, OH, 43210, USA. Hhussan@gmail.com.ORCID 0000-0002-8646-8370
Samuel AkinyeyeDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The Ohio State University, 395 W. 12th Avenue, 2nd floor, Columbus, OH, 43210, USA.
Maria MihaylovaComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Eric McLaughlinDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
ChienWei ChiangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Steven K ClintonComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
David LiebermanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Oregon Health & Science University, Portland, OR, USA.
The Ohio State University · USOregon Health & Science University · USUniversity of California Davis Medical Center · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Determining Age-Dependent Metabolic Changes in Tumors and Their MicroenvironmentDP2CA271361 · NCI · OHIO STATE UNIVERSITY · PI MIHAYLOVA, MARIA M. · 2021 to 2024
$2.3M
NCATS NIH HHS UL1 TR002733NCI NIH HHS DP2 CA271361
6 · The paper itself

Abstract

purposeSex differences exist in the associations between obesity and the risk of colorectal cancer (CRC). However, limited data exist on how sex affects CRC risk after bariatric surgery. MATERIALS AND

methodsThis retrospective cohort study used the 2012-2020 MarketScan database. We employed a propensity-score-matched analysis and precise coding to define CRC in this nationwide US study. Adjusted hazards ratio (HR) assessed CRC risk ≥ 6 months. In a restricted analysis, logistic regression with adjusted odds ratios (OR) examined CRC risk ≥ 3 years.

resultsOur sample included 327,734 controls with severe obesity and 88,630 patients with Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (VSG). The odds of cessation of diabetes mellitus medications, a surrogate for diabetes remission, were higher post-surgery vs. controls, especially in RYGB and males. In females, CRC risk decreased post-RYGB compared to controls (HR = 0.40, 95%CI: 0.18-0.87, p = 0.02). However, VSG was not associated with lower CRC risk in females. Paradoxically, in males compared to controls, CRC risk trended toward an almost significant increase, especially after 3 years or more from surgery (OR = 2.18, 95%CI: 0.97-4.89, p = 0.06). Males had a higher risk of CRC, particularly rectosigmoid cancer, than females after bariatric surgery (HR = 2.69, 95% CI: 1.35-5.38, p < 0.001). Furthermore, diabetes remission was not associated with a lower CRC risk post-surgery.

conclusionOur data suggest an increased risk of CRC in males compared to females after bariatric surgery. Compared to controls, there was a decrease in CRC risk in females' post-RYGB but not VSG. Mechanistic studies are needed to explain these differences.

Indexed as

Bariatric SurgeryColorectal NeoplasmsGastric BypassObesity, MorbidFemaleGastrectomyHumansMaleRetrospective StudiesBariatric surgeryColorectal cancerGastric bypassRisk factorSleeve gastrectomy

Identifiers

PMID35731459
OpenAlexW4283331314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.