Evidence map›Paper›PMID 35731358›Full record

ArticleAnnals of surgical oncology2022

Safety and Outcomes of Combined Pancreatic and Hepatic Resections for Metastatic Pancreatic Neuroendocrine Tumors.

Hallbera Gudmundsdottir, Ron Pery, Rondell P Graham, Cornelius A Thiels, Susanne G Warner, Rory L Smoot, Mark J Truty, Michael L Kendrick, Thorvardur R Halfdanarson, Elizabeth B Habermann and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hallbera GudmundsdottirDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0002-1297-2769
Ron PeryDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Rondell P GrahamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Cornelius A ThielsDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Susanne G WarnerDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Rory L SmootDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Mark J TrutyDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Michael L KendrickDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Thorvardur R HalfdanarsonDepartment of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Elizabeth B HabermannRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.
David M NagorneyDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Sean P ClearyDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA. cleary.sean@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApproximately 40-50% of patients with pancreatic neuroendocrine tumors (pNETs) initially present with distant metastases. Little is known about the outcomes of patients undergoing combined pancreatic and hepatic resections for this indication.

methodsPatients who underwent hepatectomy for metastatic pNETs at Mayo Clinic Rochester from 2000 to 2020 were retrospectively reviewed. Major pancreatectomy was defined as pancreaticoduodenectomy or total pancreatectomy, and major hepatectomy as right hepatectomy or trisegmentectomy. Characteristics and outcomes of patients who underwent pancreatectomy with simultaneous hepatectomy were compared with those of patients who underwent isolated hepatectomy (with or without prior history of pancreatectomy).

results205 patients who underwent hepatectomy for metastatic pNETs were identified: 131 underwent pancreatectomy with simultaneous hepatectomy and 74 underwent isolated hepatectomy. Among patients undergoing simultaneous hepatectomy, 89 patients underwent minor pancreatectomy with minor hepatectomy, 11 patients underwent major pancreatectomy with minor hepatectomy, 30 patients underwent minor pancreatectomy with major hepatectomy, and 1 patient underwent major pancreatectomy with major hepatectomy. Patients undergoing simultaneous hepatectomy had more numerous liver lesions (10 or more lesions in 54% vs. 34%, p = 0.008), but the groups were otherwise similar. Rates of any major complications (31% versus 24%, p = 0.43), hepatectomy-specific complications such as bile leak, hemorrhage, and liver failure (0.8-7.6% vs. 1.4-12%, p = 0.30-0.99), and 90-day mortality (1.5% vs. 2.7%, p = 0.62) were similar between the two groups. 5-year overall survival was 64% after combined resections and 65% after isolated hepatectomy (p = 0.93).

conclusionFor patients with metastatic pNETs, combined pancreatic and hepatic resections can be performed with acceptable morbidity and mortality in selected patients at high-volume institutions.

Indexed as

Liver NeoplasmsNeuroectodermal Tumors, PrimitiveNeuroendocrine TumorsPancreatic NeoplasmsHumansRetrospective Studies

Identifiers

PMID35731358
PMCPMC9492589
OpenAlexW4283311817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.