ArticleEnvironmental health perspectives2022
Retracted: Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study.
Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Exposure to per- and polyfluoroalkyl substances and inflammatory bowel disease: review and meta-analysis.Journal of exposure science & environmental epidemiology · 2026Pooled it
- Per- and polyfluoroalkyl substances: A novel risk factor for cardiovascular disease.Ecotoxicology and environmental safety · 2026Review
- Mechanistic Insights and Design Strategies for Hydrogel/Aerogel Sorbents in Remediation of Per- and Polyfluoroalkyl Substances.ACS environmental Au · 2026Review
- Systemic immune-inflammation index and systemic inflammation response index as predictors of mortality in participants with and without cancer.The Journal of international medical research · 2026Article
- Circulating per- and polyfluoroalkyl substances and risk of pancreatic cancer: A nested case-control study within the NYU Women's health study.Environmental pollution (Barking, Essex : 1987) · 2025Article
- [Determination of 26 perfluorinated and polyfluoroalkyl compounds in human serum by solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- Planetary Health: At the Crossroads of CVD Prevention.Current cardiology reports · 2025Review
- Association of dietary intake of folate, serum folate, and red blood cell folate with mortality risk in patients with depression: a population-based longitudinal cohort study.Journal of health, population, and nutrition · 2025Article
- Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Comment on "Exposure to Per- and Polyfluoroalkyl Substances and Mortality in US Adults: A Population-Based Cohort Study".Environmental health perspectives · 2025Article
- Response to "Comment on 'Exposure to Per- and Polyfluoroalkyl Substances and Mortality in US Adults: A Population-Based Cohort Study'".Environmental health perspectives · 2025Article
- Article
- Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration.PloS one · 2025Article
- Unveiling the Research Void: Exploring the Reproductive Effects of PFAS Compounds on Male Health.Advances in experimental medicine and biology · 2025Review
- Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality.Frontiers in nutrition · 2025Article
- Associations between per- and polyfluoroalkyl substance exposure and the prevalence of myopia in adolescents: the mediating role of serum albumin.Environmental health and preventive medicine · 2025Article
- Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.Frontiers in nutrition · 2025Article
- Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women.Environmental health : a global access science source · 2024Article
- Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston Birth Cohort.Environment international · 2024Article
- Perfluoroalkyl and polyfluoroalkyl substances and Cancer risk: results from a dose-response Meta-analysis.Journal of environmental health science & engineering · 2024Article
Corrections and comments
- Retraction · 2025-03-14Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Error in Analyses · Investigation by Third Party · · See also: https://ehp.niehs.nih.gov/doi/10.1289/EHP17149
- Retracted
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPer- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants associated with diseases such as cancer and dyslipidemia. However, few studies have investigated the association between PFAS mixture exposure and mortality in general populations.
objectivesThis study aimed to explore the association between PFAS mixture, perfluorooctanoic acid (PFOA), and perfluorooctane sulfonic acid (PFOS) and mortality in U.S. adults by a nationally representative cohort.
methodsAdults
resultsDuring the follow-up period, 1,251 participants died. In the mixture analysis, the DISCUSSION: We observed a positive association between PFAS mixture exposure and mortality among U.S. adults. Limitations of this study include the potential for unmeasured confounding, selection bias, a relatively small number of deaths, and only measuring PFAS at one point in time. Further studies with serial measures of PFAS concentrations and longer follow-ups are necessary to elucidate the association between PFAS and mortality from specific causes. https://doi.org/10.1289/EHP10393.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.