Evidence map›Paper›PMID 35731136›Full record

Trial reportJournal of diabetes investigation2022

Cholesterol efflux capacity of high-density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus.

Yuanyuan Wu, Kathryn Cb Tan, Sammy Wm Shiu, Yishan Luo, Lin Shi, Timothy Cy Kwok

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yuanyuan WuHealth Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-9996-6507
Kathryn Cb TanDepartment of Medicine, University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0001-9037-0416
Sammy Wm ShiuDepartment of Medicine, University of Hong Kong, Hong Kong, China.
Yishan LuoBrainNow Research Institute, Hong Kong, China.
Lin ShiDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
Timothy Cy KwokDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0001-9253-3549
Chinese University of Hong Kong · HKUniversity of Hong Kong · HKApplied Science and Technology Research Institute · CN

Funding

General Research Grant from the Hong Kong Research Grant Council CUHK468110
6 · The paper itself

Abstract

AIMS/

introductionTo examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. MATERIALS AND

methodsParticipants of a randomized placebo-controlled trial of 27-month vitamin B

resultsSerum HDL cholesterol at baseline was associated with better executive and memory function at follow up. Serum ApoA1 was associated with a better memory Z-score at month 18. Serum CEC and ApoA1 were not associated with Clinical Dementia Rating scale, Neuropsychological Test Battery, hippocampal volume and white matter disease on magnetic resonance imaging at baseline and whole brain atrophy rates. They were also not associated with cognitive function at month 27 and 72 on multilevel modeling. CEC and ApoA1 decreased significantly from baseline to month 27. Faster decliners in CEC had a greater increase in brain peak width of skeletonized mean diffusivity.

conclusionsHigher serum HDL cholesterol was associated with more favorable changes in memory and executive function in older people with diabetes mellitus. However, this was not due to CEC or ApoA1. A decline in CEC was associated with small vessel disease in the brain.

Indexed as

Cognitive DysfunctionDiabetes MellitusAgedBrainCholesterol, HDLHumansLipoproteins, HDLCholesterol, HDLLipoproteins, HDLCholesterol efflux capacityDementiaHigh-density lipoprotein cholesterol

Identifiers

PMID35731136
PMCPMC9623528
OpenAlexW4283310680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.