ArticleeLife2022
Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
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Who cites it
70 citing papers in PubMed.
- Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- Not just fillers: the emerging role of bone marrow adipocytes in bone and bone marrow homeostasis.Biology open · 2026Review
- Transcriptomic analysis of bone marrow adipose tissue reveals enrichment in lipid transport in response to a Western diet.Endocrinology · 2026Article
- Recent advances in glucocorticoid regulation of bone and the bone marrow niche: Genetic and pharmacological approaches to understand and prevent bone loss.Current opinion in endocrine and metabolic research · 2026Article
- Defining the potential role of the mineralocorticoid receptor in musculoskeletal health and bone crosstalk with other tissues.The Journal of endocrinology · 2026Review
- Article
- Article
- Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity.The Journal of endocrinology · 2026Article
- Expansion of bone marrow adipocytes in obese mice leads to PD-L1-driven bone marrow immunosuppression and osteoclastogenesis.Bone research · 2026Article
- Fostering the next generation of bone marrow adiposity researchers: the 3rd International Bone Marrow Adiposity Society Summer School 2025 report.Biology open · 2026Article
- Co-Treatment With rhBMP-2 and Rapamycin Modulates Osteogenesis-Adipogenesis Balance to Enhance Aged Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reexamining Fat: Exploring Diversity, Plasticity, Development, Functional Implication, and Therapeutic Options.International journal of molecular sciences · 2026Review
- Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms.Frontiers in endocrinology · 2026Review
- A catecholamine-independent pathway controlling adaptive adipocyte lipolysis.Nature metabolism · 2026Article
- Regulation of osteoclastogenesis and bone resorption by fatty acid metabolism: mechanisms and therapeutic opportunities.Frontiers in endocrinology · 2026Review
- The Multiscale Heterogeneity of Adipose Tissue in Health and Disease.Research (Washington, D.C.) · 2026Review
- Weight Loss-Associated Remodeling of Adipose Tissue Immunometabolism.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025Review
- Adipose tissue ageing: implications for metabolic health and lifespan.Nature reviews. Endocrinology · 2025Review
- Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS).Bone reports · 2025Review
10 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Ziru LiUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.ORCID 0000-0002-2755-9299
Emily BowersUniversity of Michigan Medical School, Department of Pediatrics, Ann Arbor, United States.
Junxiong ZhuDepartment of Orthopedic Surgery, University of Michigan Medical School, Ann Arbor, United States.
Hui YuUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.ORCID 0000-0001-5249-0193
Julie HardijUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Devika P BagchiUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Hiroyuki MoriUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Kenneth T LewisUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Katrina GrangerUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Rebecca L SchillUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Steven M RomanelliUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.
Simin AbrishamiUniversity of Michigan Medical School, Department of Pediatrics, Ann Arbor, United States.
Kurt D HankensonDepartment of Orthopedic Surgery, University of Michigan Medical School, Ann Arbor, United States.
Kanakadurga SingerUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.ORCID 0000-0001-8278-3800
Clifford J RosenMaine Medical Center Research Institute, Scarborough, United States.ORCID 0000-0003-3436-8199
Ormond A MacDougaldUniversity of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, United States.ORCID 0000-0001-6907-7960
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2MMICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3MInterdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MTRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9MPostdoc Stipend Supplement: Developmental Origins of Metabolic Disorders T32T32DK071212 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON, Kanakadurga Singer · 2005 to 2026
$5.4MRoles for Wnt Signaling in Adipose TissueR01DK062876 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2003 to 2018
$5.1MMultidisciplinary Training Program in Basic Diabetes ResearchT32DK101357 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN, Ormond A MacDougald · 2014 to 2026
$4.1MRegulators of Ischemic Fracture HealingR01AR066028 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANKENSON, KURT DAVID · 2015 to 2020
$2.7MCellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6MNCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR066028NIA NIH HHS R01 AG069795NICHD NIH HHS T32 HD007505NIDDK NIH HHS F31 DK122723NIDDK NIH HHS F32 DK122654NIDDK NIH HHS F32 DK123887NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK062876NIDDK NIH HHS R01 DK115583NIDDK NIH HHS R24 DK092759NIDDK NIH HHS T32 DK071212NIDDK NIH HHS T32 DK101357NIGMS NIH HHS T32 GM007863NIGMS NIH HHS T32 GM145304
Abstract
To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL,
Indexed as
Bone MarrowLipolysisAdipocytesAdipose TissueAnimalsLipaseMaleMiceLipaseadipose triglyceride lipasebonebone marrow adipocytecaloric restrictioncell biologyhematopoiesislipolysismouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.