Evidence map›Paper›PMID 35730965›Full record

ArticleMicrobiology spectrum2022

Comparative Genomics of Shiga Toxin-Producing Escherichia coli Strains Isolated from Pediatric Patients with and without Hemolytic Uremic Syndrome from 2000 to 2016 in Finland.

Xiangning Bai, Elisa Ylinen, Ji Zhang, Saara Salmenlinna, Jani Halkilahti, Harri Saxen, Aswathy Narayanan, Timo Jahnukainen, Andreas Matussek

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Comparative genomics of Shiga toxin-producingFrontiers in veterinary science · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Genome-wide association study of hemolytic uremic syndrome causing Shiga toxin-producing Escherichia coli from Sweden, 1994-2018.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Xiangning BaiDepartment of Microbiology, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-7085-6723
Elisa YlinenDepartment of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ji ZhangDiagnostic and Surveillance Services, Biosecurity New Zealand, Ministry for Primary Industries, Auckland, New Zealand.
Saara SalmenlinnaDepartment of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland.
Jani HalkilahtiDepartment of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland.
Harri SaxenDepartment of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Aswathy NarayananDivision of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutegrid.4714.6t, Stockholm, Sweden.
Timo JahnukainenDepartment of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Andreas MatussekDepartment of Microbiology, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.
University of Helsinki · FIFinnish Institute for Health and Welfare · FIKarolinska Institutet · SELinköping University · SEMinistry for Primary Industries · NZOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shiga toxin-producing Escherichia coli (STEC) infection can cause mild to severe illness, such as nonbloody or bloody diarrhea, and the fatal hemolytic uremic syndrome (HUS). The molecular mechanism underlying the variable pathogenicity of STEC infection is not fully defined so far. Here, we performed a comparative genomics study on a large collection of clinical STEC strains collected from STEC-infected pediatric patients with and without HUS in Finland over a 16-year period, aiming to identify the bacterial genetic factors that can predict the risk to cause HUS and poor renal outcome. Of 240 STEC strains included in this study, 52 (21.7%) were from pediatric patients with HUS. Serotype O157:H7 was the main cause of HUS, and Shiga toxin gene subtype

Indexed as

Escherichia coli InfectionsHemolytic-Uremic SyndromeShiga-Toxigenic Escherichia coliChildFinlandGenomicsHumansShiga ToxinShiga Toxinhemolytic uremic syndromepediatric patientsrenal outcomeShiga toxin-producing Escherichia coliwhole-genome sequencing

Identifiers

PMID35730965
PMCPMC9430701
OpenAlexW4283313949

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.