Evidence map›Paper›PMID 35730963›Full record

ArticleMicrobiology spectrum2022

Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections.

Andrew S Haynes, Andrea Prinzi, Lori J Silveira, Sarah K Parker, Jed N Lampe, Jeffrey S Kavanaugh, Alexander R Horswill, Douglas Fish

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Development ofDiscover nano · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Andrew S HaynesChildren's Hospital Colorado, Department of Pediatrics, Section of Pediatric Infectious Diseases, Aurora, Colorado, USA.ORCID 0000-0001-5486-0522
Andrea PrinziChildren's Hospital Colorado, Department of Pediatrics, Section of Pediatric Infectious Diseases, Aurora, Colorado, USA.ORCID 0000-0003-2949-5484
Lori J SilveiraUniversity of Colorado Anschutz Medical Campusgrid.430503.1, School of Medicine, Aurora, Colorado, USA.
Sarah K ParkerChildren's Hospital Colorado, Department of Pediatrics, Section of Pediatric Infectious Diseases, Aurora, Colorado, USA.
Jed N LampeUniversity of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.
Jeffrey S KavanaughDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5568-0096
Douglas FishUniversity of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.
Children's Hospital Colorado · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USVA Eastern Colorado Health Care System · US

Funding

Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–
BLRD VA I01 BX002711
6 · The paper itself

Abstract

Cephalexin and cefadroxil are oral first-generation cephalosporins used to treat methicillin-susceptible Staphylococcus aureus (MSSA) infections. Despite its shorter half-life, cephalexin is more frequently prescribed, although cefadroxil is an appealing alternative, given its slower clearance and possibility for less frequent dosing. We report comparative MIC distributions for cefadroxil and cephalexin, as well as for oxacillin, cephalothin, ceftaroline, and cefazolin, for 48 unique clinical MSSA isolates from pediatric patients with musculoskeletal infections. Both cefadroxil and cephalexin had MIC

Indexed as

CephalexinStaphylococcal InfectionsAnti-Bacterial AgentsBacteriaCefadroxilCefazolinCephalothinChildHumansMethicillinMicrobial Sensitivity TestsOxacillinStaphylococcus aureusAnti-Bacterial AgentsCefadroxilCefazolinCephalexinCephalothinMethicillinOxacillincefadroxilcephalexinMICMSSAmusculoskeletal infectionpediatric

Identifiers

PMID35730963
PMCPMC9431593
OpenAlexW4283311712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.