ReviewJournal of medicinal chemistry2022
Rings in Clinical Trials and Drugs: Present and Future.
Review in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 393 citations in OpenAlex.
- A Modular Synthesis of C5-Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry.Angewandte Chemie (International ed. in English) · 2026Article
- Remote Desaturation of Unprotected Amines and C─H Amination of Alkanes by Polarity-Matched N-Radical Cations.Angewandte Chemie (International ed. in English) · 2026Article
- A Topological and Spatial Analysis of FDA-Approved Drugs, Blood-Brain Barrier Permeants, Natural Products, and Metabolites.ChemMedChem · 2026Article
- A Novel Class of "Super-Strained" Spiro Heterocycles: Gateway to 1-Azaspiro[3.3]heptane Derivatives, and Biological Validation.Angewandte Chemie (International ed. in English) · 2026Article
- Programmable regiodivergent light-driven cyclization of acyclic 1,5-dienes unlocks rigid bicyclic architectures.Nature chemistry · 2026Article
- Article
- Formal nitrogen-to-carbon replacement in isoindolines to form indenesChemical science · 2026Article
- Transition Metal-Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones.Angewandte Chemie (International ed. in English) · 2026Article
- Modular diastereoselective synthesis of hindered cyclobutane amino nitriles through triplet nitrene-mediated ring expansion.Nature chemistry · 2026Article
- Photocatalytic Annulation of Primary Amines to δ-Lactams: Access to Privileged (Spiro)piperidine Space.Organic letters · 2026Article
- A Safe Approach to meta-Fluorinated Pyridines.Angewandte Chemie (International ed. in English) · 2026Article
- Partial Hydrogenation of Aryl-Substituted Benzothiophenes, Benzofurans and Indoles by Photocatalytic Water Activation.JACS Au · 2026Article
- Cobalt-Catalyzed Cyclohydrocarbonylations: Syntheses of Saturated Heterocycles Promoted by Light.Journal of the American Chemical Society · 2026Article
- Rapid Fragment Screening byAngewandte Chemie (International ed. in English) · 2026Article
- Modeling hERG Channel Liability: From Structural Insight to Highly Accurate Qualitative and Quantitative Models.Journal of chemical information and modeling · 2026Article
- A photochemical strategy for pyrazole to imidazole conversion.Chemical science · 2026Article
- Cholest-5-ene- and Stigmasta-5,22-diene-Based 1,3-Oxathiolan-5-one Lactones and an Aminothiazole-Diosgenin Hybrid: Synthesis and Preliminary Antimicrobial Activity.Molecules (Basel, Switzerland) · 2026Article
- Revisiting Target-Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ReLink-PyB: an adapted REINVENT-based framework for non-DSM PfDHODH inhibitor discovery.Scientific reports · 2026Article
- Based on artificial intelligence-assisted generation and in-depth in-silico evaluation of potential inhibitors targeting Stearoyl-CoA desaturase 1 (SCD-1).Scientific reports · 2026Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a comprehensive analysis of all ring systems (both heterocyclic and nonheterocyclic) in clinical trial compounds and FDA-approved drugs. We show 67% of small molecules in clinical trials comprise only ring systems found in marketed drugs, which mirrors previously published findings for newly approved drugs. We also show there are approximately 450 000 unique ring systems derived from 2.24 billion molecules currently available in synthesized chemical space, and molecules in clinical trials utilize only 0.1% of this available pool. Moreover, there are fewer ring systems in drugs compared with those in clinical trials, but this is balanced by the drug ring systems being reused more often. Furthermore, systematic changes of up to two atoms on existing drug and clinical trial ring systems give a set of 3902 future clinical trial ring systems, which are predicted to cover approximately 50% of the novel ring systems entering clinical trials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.