SynthesisThe European journal of general practice2022
A systematic review and meta-analysis of diagnostic delay in pulmonary embolism.
Synthesis in The European journal of general practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Stop coaching breathing: treat hyperventilation by talking patients back to normal ventilation.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Excess cardiovascular risk associated with community-acquired lower respiratory tract infections: a population-based nested self-controlled case-series.BMC medicine · 2026Article
- Diagnoses of pulmonary embolism from non-contrast 4DCT using image processing-derived quantitative perfusion scores.npj biomedical innovations · 2026Article
- Transferring thrombus labels from CTPA to non-contrast CT via accurate pulmonary vessel registration: a critical step toward AI-based pulmonary embolism detection.Quantitative imaging in medicine and surgery · 2026Article
- DETECT-VTE: an audit of patients with venous thromboembolism and their characteristics in general practice in the United Kingdom.Research and practice in thrombosis and haemostasis · 2026Article
- Association of transfer time and delays with outcomes for patients with acute pulmonary embolism requiring interhospital transfer: a retrospective observational study.Annals of medicine · 2025Observational
- Article
- Delayed Venous Thromboembolism Diagnosis and Mortality Risk.JAMA network open · 2025Article
- Prevalence of Electrocardiographic Abnormalities in Patients with Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- YEARS clinical decision rule for diagnosing pulmonary embolism: a prospective diagnostic cohort follow-up study in primary care.BMJ open · 2025Article
- Integration of Surgical and Coagulation Risk Factors for Predicting Postoperative Pulmonary Embolism in Thoracic Surgery: A Multi-Center Retrospective Study.International journal of general medicine · 2025Article
- Influencing factors on the time to CT in suspected pulmonary embolism: an explorative investigation.Scientific reports · 2024Article
- In-Hospital versus Out-of-Hospital Pulmonary Embolism: Clinical Characteristics, Biochemical Markers and Echocardiographic Indices.Journal of cardiovascular development and disease · 2024Article
- Changes in Pulmonary Vascular Resistance and Obstruction Score Following Acute Pulmonary Embolism in Pigs.Critical care explorations · 2024Article
- Evaluation of AT in acute pulmonary embolism with pleural effusion.Biomarkers in medicine · 2024Article
- The potential of virtual triage AI to improve early detection, care acuity alignment, and emergent care referral of life-threatening conditions.Frontiers in public health · 2024Article
- Incidence and Prognostic Role of Pleural Effusion in Patients with Pulmonary Embolism: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Clinical Characteristics, Risk Factors, and Outcomes of Acute Pulmonary Embolism in Asian Population.Journal of clinical medicine · 2022Article
- Fibrinolysis and clinical outcomes in acute pulmonary embolism. Madras medical college pulmonary embolism (M-PER) registry from India.Indian heart journalObservational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiagnostic delay in patients with pulmonary embolism (PE) is typical, yet the proportion of patients with PE that experienced delay and for how many days is less well described, nor are determinants for such delay.
objectivesThis study aimed to assess the prevalence and extent of delay in diagnosing PE.
methodsA systematic literature search was performed to identify articles reporting delays in diagnosing PE. The primary outcome was mean delay (in days) or a percentage of patients with diagnostic delay (defined as PE diagnosis more than seven days after symptom onset). The secondary outcome was determinants of delay. Random-effect meta-analyses were applied to calculate a pooled estimate for mean delay and to explore heterogeneity in subgroups.
resultsThe literature search yielded 10,933 studies, of which 24 were included in the final analysis. The pooled estimate of the mean diagnostic delay based on 12 studies was 6.3 days (95% prediction interval 2.5 to 15.8). The percentage of patients having more than seven days of delay varied between 18% and 38%. All studies assessing the determinants of coughing (
conclusionPatients may have symptoms for almost one week before PE is diagnosed and in about a quarter of patients, the diagnostic delay is even longer.
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