A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease.
Trial report in Gut and liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
In-Kyung SungDepartment of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.ORCID 0000-0002-3848-5571
Jae Young JangDepartment of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.ORCID 0000-0002-7930-1468
Kyung Sik ParkDepartment of Internal Medicine, Keimyung University College of Medicine, Daegu, Korea.ORCID 0000-0003-1874-9936
Hoon Jai ChunDepartment of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.ORCID 0000-0002-5539-361X
Eun Young KimDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.ORCID 0000-0003-3965-9964
Jun Kyu LeeDepartment of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.ORCID 0000-0002-2694-3598
Jin Seok JangDepartment of Internal Medicine, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.ORCID 0000-0001-8067-4598
Gwang Ha KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.ORCID 0000-0001-9721-5734
Su Jin HongDepartment of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.ORCID 0000-0003-2012-0360
Yong Chan LeeDepartment of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0001-8800-6906
Suck-Chei ChoiDepartment of Internal Medicine, Wonkwang University College of Medicine, Iksan, Korea.ORCID 0000-0003-1338-3306
Hyun Soo KimDepartment of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.ORCID 0000-0001-7190-0362
Tae Oh KimDepartment of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea.ORCID 0000-0002-7359-1599
Gwang Ho BaikDepartment of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.ORCID 0000-0003-1419-7484
Yong Cheol JeonDepartment of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.ORCID 0000-0002-5521-4773
Hanyang University · KRYonsei University · KRDong-A University Hospital · KRCatholic University of Korea · KRDaegu Catholic University · KRDongguk University Ilsan Hospital · KRHallym University · KRHanyang University Guri Hospital · KRKeimyung University · KRKonkuk University · KRKorea University · KRPusan National University · KRSeverance Hospital · KRSoonchunhyang University · KRWonkwang University · KR
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Background/Aims: Efficacy of proton pump inhibitors is limited in patients with nonerosive reflux disease (NERD). The aim of this study was to comparatively evaluate the efficacy and safety of esomeprazole with sodium bicarbonate and esomeprazole alone. Methods: This was a multicenter, randomized, double-blind, active-controlled, noninferiority comparative study. A total of 379 patients with NERD were randomly allocated to receive either Esoduo Results: A total of 355 patients completed the study (180 in the Esoduo Conclusions: Esoduo
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease. · full record | OpenQuestion